Preclinical experiments are carried out with ∼20-30 μm wide, ∼10 mm high parallel microbeams of hard, broad-"white"-spectrum x rays (∼50-600 keV) to investigate microbeam radiation therapy (MRT) of brain tumors in infants for whom other kinds of radiotherapy are inadequate and/or unsafe. Novel physical microdosimetry (implemented with MOSFET chips in the "edge-on" mode) and Monte Carlo computer-simulated dosimetry are described here for selected points in the peak and valley regions of a microbeam-irradiated tissue-equivalent phantom. Such microbeam irradiation causes minimal damage to normal tissues, possible because of rapid repair of their microscopic lesions. Radiation damage from an array of parallel microbeams tends to correlate with the range of peak-valley dose ratios (PVDR). This paper summarizes comparisons of our dosimetric MOSFET measurements with Monte Carlo calculations. Peak doses at depths [removed]22 mm and valley doses at all depths investigated (2 mm-62 mm) are within 2-13 % of the Monte Carlo values. These results lend credence to the use of MOSFET detector systems in edge-on mode for microplanar irradiation dosimetry.

Brauer-Krisch, E., Bravin, A., Lerch, M., Rosenfeld, A., Stepanek, J., Di Michiel, M., et al. (2003). MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility. MEDICAL PHYSICS, 30(4), 583-589 [10.1118/1.1562169].

MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility

Bravin A
Secondo
Membro del Collaboration Group
;
2003

Abstract

Preclinical experiments are carried out with ∼20-30 μm wide, ∼10 mm high parallel microbeams of hard, broad-"white"-spectrum x rays (∼50-600 keV) to investigate microbeam radiation therapy (MRT) of brain tumors in infants for whom other kinds of radiotherapy are inadequate and/or unsafe. Novel physical microdosimetry (implemented with MOSFET chips in the "edge-on" mode) and Monte Carlo computer-simulated dosimetry are described here for selected points in the peak and valley regions of a microbeam-irradiated tissue-equivalent phantom. Such microbeam irradiation causes minimal damage to normal tissues, possible because of rapid repair of their microscopic lesions. Radiation damage from an array of parallel microbeams tends to correlate with the range of peak-valley dose ratios (PVDR). This paper summarizes comparisons of our dosimetric MOSFET measurements with Monte Carlo calculations. Peak doses at depths [removed]22 mm and valley doses at all depths investigated (2 mm-62 mm) are within 2-13 % of the Monte Carlo values. These results lend credence to the use of MOSFET detector systems in edge-on mode for microplanar irradiation dosimetry.
Articolo in rivista - Articolo scientifico
Edge-on MOSFET; Microbeam radiation therapy; Microdosimetry; Synchrotron radiation;
English
2003
30
4
583
589
reserved
Brauer-Krisch, E., Bravin, A., Lerch, M., Rosenfeld, A., Stepanek, J., Di Michiel, M., et al. (2003). MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility. MEDICAL PHYSICS, 30(4), 583-589 [10.1118/1.1562169].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/348314
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