Microbeam Radiation Therapy (MRT) has the potential to treat infantile brain tumors when other kinds of radiotherapy would be excessively toxic to the developing normal brain. MRT uses extraordinarily high doses of X-rays but provides unusual resistance to radioneurotoxicity, presumably from the rapid migration of regenerative endothelial cells from dose "valleys" into dose "peaks", i.e., into directly irradiated micro-slices of tissues. We will present a novel irradiation geometry which results in a tolerable valley dose for the normal tissue and a decreased peak-to-valley dose ratio (PVDR) in the tumor area by applying an innovative cross-firing technique. We propose an MRT technique to orthogonally crossfire two arrays of parallel, nonintersecting, mutually interspersed microbeams that produces tumoricidal doses with small PVDRs where the arrays meet and tolerable radiation doses to normal tissues between the microbeams proximal and distal to the tumor in the paths of the arrays.

Brauer-Krisch, E., Requardt, H., Regnard, P., Corde, S., Siegbahn, E., Leduc, G., et al. (2004). Exploiting geometrical irradiation possibilities in MRT application. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT, 548(1-2), 69-71 [10.1016/j.nima.2005.03.068].

Exploiting geometrical irradiation possibilities in MRT application

Bravin A
Ultimo
Membro del Collaboration Group
2004

Abstract

Microbeam Radiation Therapy (MRT) has the potential to treat infantile brain tumors when other kinds of radiotherapy would be excessively toxic to the developing normal brain. MRT uses extraordinarily high doses of X-rays but provides unusual resistance to radioneurotoxicity, presumably from the rapid migration of regenerative endothelial cells from dose "valleys" into dose "peaks", i.e., into directly irradiated micro-slices of tissues. We will present a novel irradiation geometry which results in a tolerable valley dose for the normal tissue and a decreased peak-to-valley dose ratio (PVDR) in the tumor area by applying an innovative cross-firing technique. We propose an MRT technique to orthogonally crossfire two arrays of parallel, nonintersecting, mutually interspersed microbeams that produces tumoricidal doses with small PVDRs where the arrays meet and tolerable radiation doses to normal tissues between the microbeams proximal and distal to the tumor in the paths of the arrays.
Articolo in rivista - Articolo scientifico
Cross-firing; Microbeam radiation therapy; Synchrotron radiation;
English
69
71
3
Brauer-Krisch, E., Requardt, H., Regnard, P., Corde, S., Siegbahn, E., Leduc, G., et al. (2004). Exploiting geometrical irradiation possibilities in MRT application. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT, 548(1-2), 69-71 [10.1016/j.nima.2005.03.068].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/348292
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