We focused on the role of Uric Acid (UA) as a possible determinant of Heart Failure (HF) related issues in Acute Coronary Syndromes (ACS) patients. Main outcomes were acute HF and cardiogenic shock at admission, secondary outcomes were the use of Non Invasive Ventilation (NIV) and the admission Left Ventricular Ejection Fraction (LVEF). We consecutively enrolled 1269 ACS patients admitted to the cardiological Intensive Care Unit of the Niguarda and San Paolo hospitals (Milan, Italy) from June 2016 to June 2019. Median age was 68 (first-third quartile 59–77) years and males were 970 (76%). All the evaluated outcomes occurred more frequently in the hyperuricemic subjects (UA higher than 6 mg/dL for females and 7 mg/dL for males, n = 292): acute HF 35.8 vs 11.1% (p < 0.0001), cardiogenic shock 10 vs 3.1% (p < 0.0001), NIV 24.1 vs 5.1% (p < 0.0001) and lower admission LVEF (42.9±12.8 vs 49.6±9.9, p < 0.0001). By multivariable analyses, UA was confirmed to be significantly associated with all the outcomes with the following Odds Ratio (OR): acute HF OR = 1.119; 95% CI 1.019;1.229; cardiogenic shock OR = 1.157; 95% CI 1.001;1.337; NIV use OR = 1.208; 95% CI 1.078;1.354; LVEF β = -0.999; 95% CI -1.413;-0.586. We found a significant association between UA and acute HF, cardiogenic shock, NIV use and LVEF. Due to the cross-sectional nature of our study no definite answer on the direction of these relationship can be drawn and further longitudinal study on UA changes over time during an ACS hospitalization are needed.

Rebora, P., Centola, M., Morici, N., Sacco, A., Occhino, G., Viola, G., et al. (2022). Uric acid is associated with acute heart failure and shock at presentation in ACS patients. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 99(May 2022), 30-37 [10.1016/j.ejim.2022.01.018].

Uric acid is associated with acute heart failure and shock at presentation in ACS patients

Rebora P.;Centola M.;Occhino G.;Valsecchi M. G.;Giannattasio C.;Maloberti A.
2022

Abstract

We focused on the role of Uric Acid (UA) as a possible determinant of Heart Failure (HF) related issues in Acute Coronary Syndromes (ACS) patients. Main outcomes were acute HF and cardiogenic shock at admission, secondary outcomes were the use of Non Invasive Ventilation (NIV) and the admission Left Ventricular Ejection Fraction (LVEF). We consecutively enrolled 1269 ACS patients admitted to the cardiological Intensive Care Unit of the Niguarda and San Paolo hospitals (Milan, Italy) from June 2016 to June 2019. Median age was 68 (first-third quartile 59–77) years and males were 970 (76%). All the evaluated outcomes occurred more frequently in the hyperuricemic subjects (UA higher than 6 mg/dL for females and 7 mg/dL for males, n = 292): acute HF 35.8 vs 11.1% (p < 0.0001), cardiogenic shock 10 vs 3.1% (p < 0.0001), NIV 24.1 vs 5.1% (p < 0.0001) and lower admission LVEF (42.9±12.8 vs 49.6±9.9, p < 0.0001). By multivariable analyses, UA was confirmed to be significantly associated with all the outcomes with the following Odds Ratio (OR): acute HF OR = 1.119; 95% CI 1.019;1.229; cardiogenic shock OR = 1.157; 95% CI 1.001;1.337; NIV use OR = 1.208; 95% CI 1.078;1.354; LVEF β = -0.999; 95% CI -1.413;-0.586. We found a significant association between UA and acute HF, cardiogenic shock, NIV use and LVEF. Due to the cross-sectional nature of our study no definite answer on the direction of these relationship can be drawn and further longitudinal study on UA changes over time during an ACS hospitalization are needed.
Articolo in rivista - Articolo scientifico
Acute coronary syndromes; Acute pulmonary edema; Cardiogenic shock; Heart failure; Uric acid;
English
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37
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Rebora, P., Centola, M., Morici, N., Sacco, A., Occhino, G., Viola, G., et al. (2022). Uric acid is associated with acute heart failure and shock at presentation in ACS patients. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 99(May 2022), 30-37 [10.1016/j.ejim.2022.01.018].
Rebora, P; Centola, M; Morici, N; Sacco, A; Occhino, G; Viola, G; Oreglia, J; Castini, D; Persampieri, S; Sabatelli, L; Ferrante, G; Lucreziotti, S; Carugo, S; Valsecchi, M; Oliva, F; Giannattasio, C; Maloberti, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/347893
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