Synchrotron-generated X-ray microplanar beams (microbeams) are characterized by peculiar biological properties such as a remarkable tissue-sparing effect in healthy tissues including the central nervous system (CNS) and, as a direct consequence, the ability to deliver extremely high doses without induction of radionecrosis. Growing experimental evidence is showing remarkable tolerance of brain and spinal cord to irradiation with microbeam arrays delivering doses up to 400 Gy with a beam width up to 0.7 mm. Submillimetric beams can be delivered following a stereotactic design bringing to the target doses in the range of hundreds of Gray without harm to the surrounding tissues. Microbeam arrays can be used to generate cortical transections or subcortical lesions, thus enabling the non-invasive modulation of brain networks. This novel microradiosurgical approach is of great interest for the treatment of a variety of brain disorders, including functional diseases such as epilepsy and movement disorders.

Romanelli, P., Bravin, A. (2011). Synchrotron-generated microbeam radiosurgery: a novel experimental approach to modulate brain function. NEUROLOGICAL RESEARCH, 33(8), 825-831 [10.1179/016164111X13123658647445].

Synchrotron-generated microbeam radiosurgery: a novel experimental approach to modulate brain function

Bravin A
Ultimo
2011

Abstract

Synchrotron-generated X-ray microplanar beams (microbeams) are characterized by peculiar biological properties such as a remarkable tissue-sparing effect in healthy tissues including the central nervous system (CNS) and, as a direct consequence, the ability to deliver extremely high doses without induction of radionecrosis. Growing experimental evidence is showing remarkable tolerance of brain and spinal cord to irradiation with microbeam arrays delivering doses up to 400 Gy with a beam width up to 0.7 mm. Submillimetric beams can be delivered following a stereotactic design bringing to the target doses in the range of hundreds of Gray without harm to the surrounding tissues. Microbeam arrays can be used to generate cortical transections or subcortical lesions, thus enabling the non-invasive modulation of brain networks. This novel microradiosurgical approach is of great interest for the treatment of a variety of brain disorders, including functional diseases such as epilepsy and movement disorders.
Articolo in rivista - Articolo scientifico
Brain; Cortex; Epilepsy; Microbeam; Movement disorders; Radiosurgery; Spine; Synchrotron; Transection;
English
19-lug-2013
2011
33
8
825
831
reserved
Romanelli, P., Bravin, A. (2011). Synchrotron-generated microbeam radiosurgery: a novel experimental approach to modulate brain function. NEUROLOGICAL RESEARCH, 33(8), 825-831 [10.1179/016164111X13123658647445].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/347855
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