The sera and the CSFs from 157 Multiple Sclerosis (MS) patients and 43 other neurological diseases (OND) cases have been evaluated for the presence of HTLVI antibodies. A commercial passive agglutination assay (PPA), an indirect fluorescence assay (IFA), and a Western Immunoblotting (WIB) performed in our laboratories have been employed. No OND samples showed HTLVI antibodies, while 14 sera and 1 CSF from MS patients resulted positive by PPA and 4 sera were positive with the IFA. When tested with WIB 6 MS sera showed a reactivity against one or more HTLVI proteins. Our results lead us to affirm that in a small number of MS patients, when sensitive tests are employed, it is possible to observe an antibody response toward proteins that share one or more epitope with HTLVI antigens.

Ferrante, P., Seresella, M., Cocuzza, C., Caputo, D., Cattaneo, E., Achilli, G., et al. (1990). HTLVI antibodies in multiple sclerosis and other neurological diseases. ACTA NEUROLOGICA, 12(1), 95-9.

HTLVI antibodies in multiple sclerosis and other neurological diseases

COCUZZA, CLEMENTINA ELVEZIA;
1990

Abstract

The sera and the CSFs from 157 Multiple Sclerosis (MS) patients and 43 other neurological diseases (OND) cases have been evaluated for the presence of HTLVI antibodies. A commercial passive agglutination assay (PPA), an indirect fluorescence assay (IFA), and a Western Immunoblotting (WIB) performed in our laboratories have been employed. No OND samples showed HTLVI antibodies, while 14 sera and 1 CSF from MS patients resulted positive by PPA and 4 sera were positive with the IFA. When tested with WIB 6 MS sera showed a reactivity against one or more HTLVI proteins. Our results lead us to affirm that in a small number of MS patients, when sensitive tests are employed, it is possible to observe an antibody response toward proteins that share one or more epitope with HTLVI antigens.
Articolo in rivista - Articolo scientifico
HTLV-I Antibodies; Nervous System Diseases; Multiple Sclerosis; Humans
English
95-9
Ferrante, P., Seresella, M., Cocuzza, C., Caputo, D., Cattaneo, E., Achilli, G., et al. (1990). HTLVI antibodies in multiple sclerosis and other neurological diseases. ACTA NEUROLOGICA, 12(1), 95-9.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/34676
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