The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.
Serduc, R., Braeuer-Krisch, E., Bouchet, A., Renaud, L., Brochard, T., Bravin, A., et al. (2009). First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy. JOURNAL OF SYNCHROTRON RADIATION, 16(4), 587-590 [10.1107/S0909049509012485].
First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy
Bravin AMembro del Collaboration Group
;
2009
Abstract
The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.
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