We report on significant advances and new results concerning a recently developed method for grating-based hard x-ray phase tomography. We demonstrate how the soft tissue sensitivity of the technique is increased and show in vitro tomographic images of a tumor bearing rat brain sample, without use of contrast agents. In particular, we observe that the brain tumor and the white and gray brain matter structure in a rat's cerebellum are clearly resolved. The results are potentially interesting from a clinical point of view, since a similar approach using three transmission gratings can be implemented with more readily available x-ray sources, such as standard x-ray tubes. Moreover, the results open the way to in vivo experiments in the near future.
Pfeiffer, F., Bunk, O., David, C., Bech, M., Le Duc, G., Bravin, A., et al. (2007). High-resolution brain tumor visualization using three-dimensional x-ray phase contrast tomography. PHYSICS IN MEDICINE AND BIOLOGY, 52(23), 6923-6930 [10.1088/0031-9155/52/23/010].
High-resolution brain tumor visualization using three-dimensional x-ray phase contrast tomography
Bravin APenultimo
Membro del Collaboration Group
;
2007
Abstract
We report on significant advances and new results concerning a recently developed method for grating-based hard x-ray phase tomography. We demonstrate how the soft tissue sensitivity of the technique is increased and show in vitro tomographic images of a tumor bearing rat brain sample, without use of contrast agents. In particular, we observe that the brain tumor and the white and gray brain matter structure in a rat's cerebellum are clearly resolved. The results are potentially interesting from a clinical point of view, since a similar approach using three transmission gratings can be implemented with more readily available x-ray sources, such as standard x-ray tubes. Moreover, the results open the way to in vivo experiments in the near future.File | Dimensione | Formato | |
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