The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood-brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47 x 47 muM(2) pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals.

Adam, J., Nemoz, C., Bravin, A., Fiedler, S., Bayat, S., Monfraix, S., et al. (2005). High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 25(2), 145-153 [10.1038/sj.jcbfm.9600017].

High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma

Bravin A
Membro del Collaboration Group
;
2005

Abstract

The authors previously provided evidence of synchrotron radiation computed tomography (SRCT) efficacy for quantitative in vivo brain perfusion measurements using monochromatic X-ray beams. However, this technique was limited for small-animal studies by partial volume effects. In this paper, high-resolution absolute cerebral blood volume and blood-brain barrier permeability coefficient measurements were obtained on a rat glioma model using SRCT and a CCD camera (47 x 47 muM(2) pixel size). This is the first report of in vivo high-resolution brain vasculature parameter assessment. The work gives interesting perspectives to quantify brain hemodynamic changes accurately in healthy and pathological small animals.
Articolo in rivista - Articolo scientifico
cerebral blood flow, high resolution, X-rays
English
2005
25
2
145
153
reserved
Adam, J., Nemoz, C., Bravin, A., Fiedler, S., Bayat, S., Monfraix, S., et al. (2005). High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 25(2), 145-153 [10.1038/sj.jcbfm.9600017].
File in questo prodotto:
File Dimensione Formato  
Adam2-JCBF.pdf

Solo gestori archivio

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 314.37 kB
Formato Adobe PDF
314.37 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/342931
Citazioni
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 28
Social impact