Glycoproteins and glycolipids play central roles in human health and disease, and their mimetics are primary candidates for drug development. Our understanding of the molecular level of phenomena based on molecular recognition of oligosaccharides by specific receptors has taken tremendous advantage from their chemical synthesis, which provides homogeneous material not attainable from biosynthetic systems. This review summarizes chemoselective approaches for the assembly of neoglycoconjugates. The objective of these methods is to make glycoconjugate synthesis accessible to a broader community, thus accelerating progress in biotechnology

Peri, F. (2003). Extending chemoselective ligation to sugar chemistry:convergent assembly of bioactive neoglycoconjugates. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 3(7), 651-658 [10.2174/1389557033487700].

Extending chemoselective ligation to sugar chemistry:convergent assembly of bioactive neoglycoconjugates

Peri, F.
2003

Abstract

Glycoproteins and glycolipids play central roles in human health and disease, and their mimetics are primary candidates for drug development. Our understanding of the molecular level of phenomena based on molecular recognition of oligosaccharides by specific receptors has taken tremendous advantage from their chemical synthesis, which provides homogeneous material not attainable from biosynthetic systems. This review summarizes chemoselective approaches for the assembly of neoglycoconjugates. The objective of these methods is to make glycoconjugate synthesis accessible to a broader community, thus accelerating progress in biotechnology
Articolo in rivista - Articolo scientifico
chemoselective ligation; synthetic chemistry; medicinal chemistry
English
2003
3
7
651
658
none
Peri, F. (2003). Extending chemoselective ligation to sugar chemistry:convergent assembly of bioactive neoglycoconjugates. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 3(7), 651-658 [10.2174/1389557033487700].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/34275
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