Description of purpose: Treatment of osteoarthritis in stages of reversible disease requires high resolution visualization of early cartilage damage and of subchondral bone. Here, DEI (Diffraction Enhanced Imaging) is compared to MRI, computed X-ray tomography (CT) and ultrasound (UI) in its ability to detect early degeneration of articular cartilage. In contrast to conventional absorptive X-ray examination where cartilage is poorly visible DEI captures cartilage by detection of selected refraction. Methods: Human femoral heads were investigated by macroscopic inspection, conventional X-ray examination, DEI, MRI, CT, UI and histology. DEI is an imaging technique applying a monochromatic parallel synchrotron X-ray beam. Image features were verified by histology. Results: DEI, MRI and ultrasound lead to interpretable images of cartilage. Of all techniques, DEI provided highest image resolution revealing the structural tissue architecture. MRI needs a very long exposure time (more than 5 hours) to achieve comparable quality. Application of ultrasound is limited because of joint geometry and, at high sound frequency, the necessity of close contact between cartilage and transducer. DEI is an experimental technique which needs synchrotron radiation. Conclusion: DEI is a very promising imaging technique for visualization of cartilage and bone. It may serve as an excellent analytical tool for experimental studies. Our pictures show a part of future of optimised techniques for imaging. Synchrotron based DEI may lead the way towards optimisation of improved techniques for imaging. Upon development of adequate small scale X-ray sources, DEI will also be an important supplementation for medical imaging.

Wagner, A., Aurich, M., Stoessel, M., Sieber, N., Wetzel, W., Mollenhauer, J., et al. (2005). Chance and limit of imaging of articular cartilage in vitro in healthy and arthritic joints - DEI (Diffraction Enhanced Imaging) in comparison with MRI, CT and ultrasound. In Proceedings of SPIE volume 5746 (pp.542-549) [10.1117/12.589614].

Chance and limit of imaging of articular cartilage in vitro in healthy and arthritic joints - DEI (Diffraction Enhanced Imaging) in comparison with MRI, CT and ultrasound

Bravin A
Membro del Collaboration Group
;
2005

Abstract

Description of purpose: Treatment of osteoarthritis in stages of reversible disease requires high resolution visualization of early cartilage damage and of subchondral bone. Here, DEI (Diffraction Enhanced Imaging) is compared to MRI, computed X-ray tomography (CT) and ultrasound (UI) in its ability to detect early degeneration of articular cartilage. In contrast to conventional absorptive X-ray examination where cartilage is poorly visible DEI captures cartilage by detection of selected refraction. Methods: Human femoral heads were investigated by macroscopic inspection, conventional X-ray examination, DEI, MRI, CT, UI and histology. DEI is an imaging technique applying a monochromatic parallel synchrotron X-ray beam. Image features were verified by histology. Results: DEI, MRI and ultrasound lead to interpretable images of cartilage. Of all techniques, DEI provided highest image resolution revealing the structural tissue architecture. MRI needs a very long exposure time (more than 5 hours) to achieve comparable quality. Application of ultrasound is limited because of joint geometry and, at high sound frequency, the necessity of close contact between cartilage and transducer. DEI is an experimental technique which needs synchrotron radiation. Conclusion: DEI is a very promising imaging technique for visualization of cartilage and bone. It may serve as an excellent analytical tool for experimental studies. Our pictures show a part of future of optimised techniques for imaging. Synchrotron based DEI may lead the way towards optimisation of improved techniques for imaging. Upon development of adequate small scale X-ray sources, DEI will also be an important supplementation for medical imaging.
paper
Cartilage imaging; Comparison DEI with MRI; CT and ultrasound; DEI (Diffraction Enhanced Imaging); X-ray imaging;
English
Medical Imaging 2005 - Physiology, Function, and Structure from Medical Images
2005
Proceedings of SPIE volume 5746
0-8194-5720-5
2005
5746
2
542
549
59
open
Wagner, A., Aurich, M., Stoessel, M., Sieber, N., Wetzel, W., Mollenhauer, J., et al. (2005). Chance and limit of imaging of articular cartilage in vitro in healthy and arthritic joints - DEI (Diffraction Enhanced Imaging) in comparison with MRI, CT and ultrasound. In Proceedings of SPIE volume 5746 (pp.542-549) [10.1117/12.589614].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/342482
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