Pharmacological strategies for chemotherapy-induced peripheral neurotoxicity (CIPN) are very limited. We systematically reviewed data on rehabilitation, exercise, physical therapy, and other physical non-pharmacological interventions and offered evidence-based recommendations for the prevention and treatment of CIPN. A literature search using PubMed, Web of Science and CINAHL was conducted from database inception until May 31st, 2021. 2791 records were title-abstract screened, 71 papers were full-text screened, 41 studies were included, 21 on prevention and 20 on treatment of CIPN. Treatment type, cancer type, chemotherapy compounds were heterogeneous, sample size was small (median: N = 34) and intention-to-treat analysis was lacking in 26/41 reports. Because of the methodological issues of included studies, the reviewed evidence should be considered as preliminary. Exercise, endurance, strength, balance, and sensorimotor training have been studied in low-to-moderate quality studies, while the evidence for other treatments is preliminary/inconclusive. We offer recommendation for the design of future trials on CIPN.

Tamburin, S., Park, S., Schenone, A., Mantovani, E., Hamedani, M., Alberti, P., et al. (2022). Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: systematic review and evidence-based recommendations. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 171(March 2022) [10.1016/j.critrevonc.2021.103575].

Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: systematic review and evidence-based recommendations

Alberti, Paola;Mazzucchelli, Miryam;Cavaletti, Guido;
2022

Abstract

Pharmacological strategies for chemotherapy-induced peripheral neurotoxicity (CIPN) are very limited. We systematically reviewed data on rehabilitation, exercise, physical therapy, and other physical non-pharmacological interventions and offered evidence-based recommendations for the prevention and treatment of CIPN. A literature search using PubMed, Web of Science and CINAHL was conducted from database inception until May 31st, 2021. 2791 records were title-abstract screened, 71 papers were full-text screened, 41 studies were included, 21 on prevention and 20 on treatment of CIPN. Treatment type, cancer type, chemotherapy compounds were heterogeneous, sample size was small (median: N = 34) and intention-to-treat analysis was lacking in 26/41 reports. Because of the methodological issues of included studies, the reviewed evidence should be considered as preliminary. Exercise, endurance, strength, balance, and sensorimotor training have been studied in low-to-moderate quality studies, while the evidence for other treatments is preliminary/inconclusive. We offer recommendation for the design of future trials on CIPN.
Articolo in rivista - Review Essay
Chemotherapy-induced peripheral neurotoxicity (CIPN); Evidence-based medicine; Exercise; Physical therapy; Rehabilitation; Treatment;
English
28-dic-2021
2022
171
March 2022
103575
none
Tamburin, S., Park, S., Schenone, A., Mantovani, E., Hamedani, M., Alberti, P., et al. (2022). Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: systematic review and evidence-based recommendations. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 171(March 2022) [10.1016/j.critrevonc.2021.103575].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/342395
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