ObjectiveTo assess the delay between the disease onset and the beginning of methotrexate (MTX) treatment in RA patients and to evaluate the Italian rheumatologists' adherence to the EULAR 2013 recommendations.MethodsMITRA is an Italian multicentre observational study carried out on DMARD-naive RA patients recruited in an 18-month period starting from 2015. The data related to the patients' characteristics at baseline will be presented.Results332 patients from 13 Italian centres were recruited: the median delay between the onset of symptoms and the beginning of MTX was 197 days (102-431); in 20% of patients a treatment with DMARDs was started within the first 90 days from the onset of symptoms. The clinical target selected was DAS28 remission in 642% of cases and low disease activity in 35.8%. Among patients in DAS28 high disease activity, 92.6% received a control visit which was rescheduled within the first 3 months, similarly to those in DAS28 moderate disease activity (91.6%). A DMARD monotherapy was prescribed in 319 patients, while a combined therapy of DMARDs was preferred in 13 cases; 282 patients were treated with MTX. Glucocorticoids were prescribed in 229 patients: the median dosage was of 5 mg (IQR 5-7.5) of prednisone equivalent/day.ConclusionDiagnostic delay in RA patients continues to be longer than expected. The choice of low disease activity as a target is still very frequent and tight control does not seem to be based on disease activity. This paper offers a realistic and detailed picture of the clinical practice among Italian rheumatologists.

Benaglio, F., Fornaro, M., Montecucco, C., Raffeiner, B., Di Franco, M., Iannuccelli, C., et al. (2021). Methotrexate in Italian patients wiTh Rheumatoid Arthritis (MITRA study): an observational study about the use of methotrexate in early RA patients and the adherence to the EULAR 2013 recommendations. A project of the Italian Society for Rheumatology. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 39(5), 1077-1084.

Methotrexate in Italian patients wiTh Rheumatoid Arthritis (MITRA study): an observational study about the use of methotrexate in early RA patients and the adherence to the EULAR 2013 recommendations. A project of the Italian Society for Rheumatology

Zanetti, A;Scire, CA;
2021

Abstract

ObjectiveTo assess the delay between the disease onset and the beginning of methotrexate (MTX) treatment in RA patients and to evaluate the Italian rheumatologists' adherence to the EULAR 2013 recommendations.MethodsMITRA is an Italian multicentre observational study carried out on DMARD-naive RA patients recruited in an 18-month period starting from 2015. The data related to the patients' characteristics at baseline will be presented.Results332 patients from 13 Italian centres were recruited: the median delay between the onset of symptoms and the beginning of MTX was 197 days (102-431); in 20% of patients a treatment with DMARDs was started within the first 90 days from the onset of symptoms. The clinical target selected was DAS28 remission in 642% of cases and low disease activity in 35.8%. Among patients in DAS28 high disease activity, 92.6% received a control visit which was rescheduled within the first 3 months, similarly to those in DAS28 moderate disease activity (91.6%). A DMARD monotherapy was prescribed in 319 patients, while a combined therapy of DMARDs was preferred in 13 cases; 282 patients were treated with MTX. Glucocorticoids were prescribed in 229 patients: the median dosage was of 5 mg (IQR 5-7.5) of prednisone equivalent/day.ConclusionDiagnostic delay in RA patients continues to be longer than expected. The choice of low disease activity as a target is still very frequent and tight control does not seem to be based on disease activity. This paper offers a realistic and detailed picture of the clinical practice among Italian rheumatologists.
Articolo in rivista - Articolo scientifico
adherence; delay; EULAR recommendations; rheumatoid arthritis; treat to target;
English
1077
1084
8
Benaglio, F., Fornaro, M., Montecucco, C., Raffeiner, B., Di Franco, M., Iannuccelli, C., et al. (2021). Methotrexate in Italian patients wiTh Rheumatoid Arthritis (MITRA study): an observational study about the use of methotrexate in early RA patients and the adherence to the EULAR 2013 recommendations. A project of the Italian Society for Rheumatology. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 39(5), 1077-1084.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/342206
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