Atypical chronic myeloid leukemia is a rare disease whose pathogenesis has long been debated. It currently belongs to the group of myelodysplastic/myeloproliferative disorders. In this review, an overview on the current knowledge about diagnosis, prognosis, and genetics is presented, with a major focus on the recent molecular findings. We describe here the molecular pathogenesis of the disease, focusing on the mechanisms of action of the main mutations as well as on gene expression profiling. We also present the treatment options focusing on emerging targeted therapies.

Fontana, D., Gambacorti Passerini, C., Piazza, R. (2021). Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia. FRONTIERS IN ONCOLOGY, 11(11 November 2021) [10.3389/fonc.2021.756348].

Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia

Fontana D.
Primo
;
Gambacorti Passerini C.
Secondo
;
Piazza R.
Ultimo
2021

Abstract

Atypical chronic myeloid leukemia is a rare disease whose pathogenesis has long been debated. It currently belongs to the group of myelodysplastic/myeloproliferative disorders. In this review, an overview on the current knowledge about diagnosis, prognosis, and genetics is presented, with a major focus on the recent molecular findings. We describe here the molecular pathogenesis of the disease, focusing on the mechanisms of action of the main mutations as well as on gene expression profiling. We also present the treatment options focusing on emerging targeted therapies.
Articolo in rivista - Review Essay
aCML; BCR-ABL1-negative; ETNK1; MDS/MPN; molecular pathogenesis; SETBP1;
English
2021
11
11 November 2021
756348
open
Fontana, D., Gambacorti Passerini, C., Piazza, R. (2021). Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia. FRONTIERS IN ONCOLOGY, 11(11 November 2021) [10.3389/fonc.2021.756348].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/340225
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