The most common arrhythmia associated with COronaVIrus-related Disease (COVID) infection is sinus tachycardia. It is not known if high Heart Rate (HR) in COVID is simply a marker of higher systemic response to sepsis or if its persistence could be related to a long-term autonomic dysfunction. The aim of our work is to assess the prevalence of elevated HR at discharge in patients hospitalized for COVID-19 and to evaluate the variables associated with it. We enrolled 697 cases of SARS-CoV2 infection admitted in our hospital after February 21 and discharged within 23 July 2020. We collected data on clinical history, vital signs, laboratory tests and pharmacological treat-ment. Severe disease was defined as the need for Intensive Care Unit (ICU) admission and/or me-chanical ventilation. Median age was 59 years (first-third quartile 49, 74), and male was the preva-lent gender (60.1%). 84.6% of the subjects showed a SARS-CoV-2 related pneumonia, and 13.2% resulted in a severe disease. Mean HR at admission was 90 ± 18 bpm with a mean decrease of 10 bpm to discharge. Only 5.5% of subjects presented HR > 100 bpm at discharge. Significant predictors of discharge HR at multiple linear model were admission HR (mean increase = β = 0.17 per bpm, 95% CI 0.11; 0.22, p < 0.001), haemoglobin (ß = −0.64 per g/dL, 95% CI −1.19; −0.09, p = 0.023) and severe disease (ß = 8.42, 95% CI 5.39; 11.45, p < 0.001). High HR at discharge in COVID-19 patients is not such a frequent consequence, but when it occurs it seems strongly related to a severe course of the disease.

Maloberti, A., Ughi, N., Bernasconi, D., Rebora, P., Cartella, I., Grasso, E., et al. (2021). Heart rate in patients with sars-cov-2 infection: Prevalence of high values at discharge and relationship with disease severity. JOURNAL OF CLINICAL MEDICINE, 10(23) [10.3390/jcm10235590].

Heart rate in patients with sars-cov-2 infection: Prevalence of high values at discharge and relationship with disease severity

Maloberti A.
;
Bernasconi D. P.;Rebora P.;Grasso E.;Verde A.;Valsecchi M. G.;Giannattasio C.
2021

Abstract

The most common arrhythmia associated with COronaVIrus-related Disease (COVID) infection is sinus tachycardia. It is not known if high Heart Rate (HR) in COVID is simply a marker of higher systemic response to sepsis or if its persistence could be related to a long-term autonomic dysfunction. The aim of our work is to assess the prevalence of elevated HR at discharge in patients hospitalized for COVID-19 and to evaluate the variables associated with it. We enrolled 697 cases of SARS-CoV2 infection admitted in our hospital after February 21 and discharged within 23 July 2020. We collected data on clinical history, vital signs, laboratory tests and pharmacological treat-ment. Severe disease was defined as the need for Intensive Care Unit (ICU) admission and/or me-chanical ventilation. Median age was 59 years (first-third quartile 49, 74), and male was the preva-lent gender (60.1%). 84.6% of the subjects showed a SARS-CoV-2 related pneumonia, and 13.2% resulted in a severe disease. Mean HR at admission was 90 ± 18 bpm with a mean decrease of 10 bpm to discharge. Only 5.5% of subjects presented HR > 100 bpm at discharge. Significant predictors of discharge HR at multiple linear model were admission HR (mean increase = β = 0.17 per bpm, 95% CI 0.11; 0.22, p < 0.001), haemoglobin (ß = −0.64 per g/dL, 95% CI −1.19; −0.09, p = 0.023) and severe disease (ß = 8.42, 95% CI 5.39; 11.45, p < 0.001). High HR at discharge in COVID-19 patients is not such a frequent consequence, but when it occurs it seems strongly related to a severe course of the disease.
Articolo in rivista - Articolo scientifico
COVID-19; Heart rate; Infection severity; SARS-CoV-2;
English
Gold Open Access
Maloberti, A., Ughi, N., Bernasconi, D., Rebora, P., Cartella, I., Grasso, E., et al. (2021). Heart rate in patients with sars-cov-2 infection: Prevalence of high values at discharge and relationship with disease severity. JOURNAL OF CLINICAL MEDICINE, 10(23) [10.3390/jcm10235590].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/339678
Citazioni
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 5
Social impact