Malignant hyperthermia occurs in humans with several congenital myopathies, usually in response to general anesthesia. Commonly, individuals who develop this syndrome lack symptoms of muscle disease, and their muscle lacks specific pathological changes. A biochemical marker for this myopathy has not previously been available; we found activity of adenylate cyclase and content of cyclic AMP to be abnormally high in skeletal muscle. Secondary modification of protein phosphorylation could explain observed abnormalities of phosphorylase activation and sarcoplasmic reticulum function.

Willner, J., Cerri, C., & Wood, D. (1981). High skeletal muscle adenylate cyclase in malignant hyperthermia. THE JOURNAL OF CLINICAL INVESTIGATION, 68(5), 1119-1124 [10.1172/JCI110355].

High skeletal muscle adenylate cyclase in malignant hyperthermia

CERRI, CESARE GIUSEPPE;
1981

Abstract

Malignant hyperthermia occurs in humans with several congenital myopathies, usually in response to general anesthesia. Commonly, individuals who develop this syndrome lack symptoms of muscle disease, and their muscle lacks specific pathological changes. A biochemical marker for this myopathy has not previously been available; we found activity of adenylate cyclase and content of cyclic AMP to be abnormally high in skeletal muscle. Secondary modification of protein phosphorylation could explain observed abnormalities of phosphorylase activation and sarcoplasmic reticulum function.
Articolo in rivista - Articolo scientifico
Scientifica
malignant hyperthermia
English
Willner, J., Cerri, C., & Wood, D. (1981). High skeletal muscle adenylate cyclase in malignant hyperthermia. THE JOURNAL OF CLINICAL INVESTIGATION, 68(5), 1119-1124 [10.1172/JCI110355].
Willner, J; Cerri, C; Wood, D
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/33806
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