We report a subtype of immune-mediated encephalitis associated with COVID-19, which closely mimics acute-onset sporadic Creutzfeldt-Jakob disease. A 64-year-old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS-CoV-2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14-3-3 protein. RT-QuIC analysis was negative. High levels of pro-inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6-month follow-up.
Beretta, S., Stabile, A., Balducci, C., DiFrancesco, J., Patruno, A., Rona, R., et al. (2021). COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 8(12), 2314-2318 [10.1002/acn3.51479].
Citazione: | Beretta, S., Stabile, A., Balducci, C., DiFrancesco, J., Patruno, A., Rona, R., et al. (2021). COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 8(12), 2314-2318 [10.1002/acn3.51479]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease | |
Autori: | Beretta, S; Stabile, A; Balducci, C; DiFrancesco, J; Patruno, A; Rona, R; Bombino, M; Capraro, C; Andreetta, F; Cavalcante, P; Moda, F; Citerio, G; Foti, G; Bogliun, G; Ferrarese, C | |
Autori: | ||
Data di pubblicazione: | 2021 | |
Lingua: | English | |
Rivista: | ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/acn3.51479 | |
Appare nelle tipologie: | 01 - Articolo su rivista |
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