Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. We scrutinized the production of IFNs along the respiratory tract of COVID-19 patients and found that high levels of IFN-III, and to a lesser extent IFN-I, characterize the upper airways of patients with high viral burden but reduced disease risk or severity. Production of specific IFN-III, but not IFN-I, members denotes patients with a mild pathology and efficiently drives the transcription of genes that protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In contrast, compared to subjects with other infectious or noninfectious lung pathologies, IFNs are overrepresented in the lower airways of patients with severe COVID-19 that exhibit gene pathways associated with increased apoptosis and decreased proliferation. Our data demonstrate a dynamic production of IFNs in SARS-CoV-2-infected patients and show IFNs play opposing roles at distinct anatomical sites.

Sposito, B., Broggi, A., Pandolfi, L., Crotta, S., Clementi, N., Ferrarese, R., et al. (2021). The interferon landscape along the respiratory tract impacts the severity of COVID-19. CELL, 184(19), 4953-4968.e16 [10.1016/j.cell.2021.08.016].

The interferon landscape along the respiratory tract impacts the severity of COVID-19

Sposito B.
Primo
;
Broggi A.
;
Pandolfi L.;Marongiu L.;Facchini F. A.;Zanoni I.
2021

Abstract

Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. We scrutinized the production of IFNs along the respiratory tract of COVID-19 patients and found that high levels of IFN-III, and to a lesser extent IFN-I, characterize the upper airways of patients with high viral burden but reduced disease risk or severity. Production of specific IFN-III, but not IFN-I, members denotes patients with a mild pathology and efficiently drives the transcription of genes that protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In contrast, compared to subjects with other infectious or noninfectious lung pathologies, IFNs are overrepresented in the lower airways of patients with severe COVID-19 that exhibit gene pathways associated with increased apoptosis and decreased proliferation. Our data demonstrate a dynamic production of IFNs in SARS-CoV-2-infected patients and show IFNs play opposing roles at distinct anatomical sites.
Si
Articolo in rivista - Articolo scientifico
Scientifica
airways; COVID-19; dendritic cell; epithelial cell; interferon; lung; pattern recognition receptor; SARS-CoV-2; Type I IFN; Type III IFN;
English
4953
4968.e16
Hybrid Gold Open Access• Green Open Access
Sposito, B., Broggi, A., Pandolfi, L., Crotta, S., Clementi, N., Ferrarese, R., et al. (2021). The interferon landscape along the respiratory tract impacts the severity of COVID-19. CELL, 184(19), 4953-4968.e16 [10.1016/j.cell.2021.08.016].
Sposito, B; Broggi, A; Pandolfi, L; Crotta, S; Clementi, N; Ferrarese, R; Sisti, S; Criscuolo, E; Spreafico, R; Long, J; Ambrosi, A; Liu, E; Frangipane, V; Saracino, L; Bozzini, S; Marongiu, L; Facchini, F; Bottazzi, A; Fossali, T; Colombo, R; Clementi, M; Tagliabue, E; Chou, J; Pontiroli, A; Meloni, F; Wack, A; Mancini, N; Zanoni, I
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/336953
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