Background and aim: How symptoms and antibodies related to SARS-CoV-2 infection develop in patients with celiac disease (CD) is unclear. We aimed to investigate the impact of SARS-CoV-2 infection in CD patients. Methods: CD patients were interviewed about the development of COVID-19 symptoms, compliance with anti-virus measures and adherence to a gluten-free diet (GFD). The presence of anti-SARS-CoV-2 IgG and IgA (anti-RBD and N proteins) was compared to that in non-CD subjects. Expression of the duodenal ACE2 receptor was investigated. When available, data on duodenal histology, anti-tissue transglutaminase IgA (tTGA), comorbidities and GFD adherence were analyzed. Results: Of 362 CD patients, 42 (12%) reported COVID-19 symptoms and 21% of these symptomatic patients presented anti-SARS-CoV-2 Ig. Overall, 18% of CD patients showed anti-SARS-CoV-2 Ig versus 25% of controls (p = 0.18). CD patients had significantly lower levels of anti-N IgA. tTGA, duodenal atrophy, GFD adherence or other comorbidities did not influence symptoms and/or antibodies. The ACE2 receptor was detected in the non-atrophic duodenal mucosa of patients; atrophy was associated with lower expression of the ACE2 receptor. Conclusion: CD patients have an anti-SARS-CoV-2 Ig profile similar to non-celiac controls, except for anti-N IgA. No risk factors were identified among CD parameters and GFD adherence.

Elli, L., Facciotti, F., Lombardo, V., Scricciolo, A., Sanders, D., Vaira, V., et al. (2022). Anti-SARS-CoV-2 immunoglobulin profile in patients with celiac disease living in a high incidence area. DIGESTIVE AND LIVER DISEASE, 54(1), 3-9 [10.1016/j.dld.2021.08.027].

Anti-SARS-CoV-2 immunoglobulin profile in patients with celiac disease living in a high incidence area

Facciotti F.;Barisani D.;
2022

Abstract

Background and aim: How symptoms and antibodies related to SARS-CoV-2 infection develop in patients with celiac disease (CD) is unclear. We aimed to investigate the impact of SARS-CoV-2 infection in CD patients. Methods: CD patients were interviewed about the development of COVID-19 symptoms, compliance with anti-virus measures and adherence to a gluten-free diet (GFD). The presence of anti-SARS-CoV-2 IgG and IgA (anti-RBD and N proteins) was compared to that in non-CD subjects. Expression of the duodenal ACE2 receptor was investigated. When available, data on duodenal histology, anti-tissue transglutaminase IgA (tTGA), comorbidities and GFD adherence were analyzed. Results: Of 362 CD patients, 42 (12%) reported COVID-19 symptoms and 21% of these symptomatic patients presented anti-SARS-CoV-2 Ig. Overall, 18% of CD patients showed anti-SARS-CoV-2 Ig versus 25% of controls (p = 0.18). CD patients had significantly lower levels of anti-N IgA. tTGA, duodenal atrophy, GFD adherence or other comorbidities did not influence symptoms and/or antibodies. The ACE2 receptor was detected in the non-atrophic duodenal mucosa of patients; atrophy was associated with lower expression of the ACE2 receptor. Conclusion: CD patients have an anti-SARS-CoV-2 Ig profile similar to non-celiac controls, except for anti-N IgA. No risk factors were identified among CD parameters and GFD adherence.
Articolo in rivista - Articolo scientifico
ACE2 receptor; Celiac disease; COVID-19; Gluten; SARS-CoV-2; Small bowel;
English
10-set-2021
2022
54
1
3
9
reserved
Elli, L., Facciotti, F., Lombardo, V., Scricciolo, A., Sanders, D., Vaira, V., et al. (2022). Anti-SARS-CoV-2 immunoglobulin profile in patients with celiac disease living in a high incidence area. DIGESTIVE AND LIVER DISEASE, 54(1), 3-9 [10.1016/j.dld.2021.08.027].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/335925
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