Invariant Natural Killer T (iNKT) cells are a non-conventional, innate-like, T cell population that recognize lipid antigens presented by the cluster of differentiation (CD)1d molecule. Although iNKT cells are mostly known for mediating several immune responses due to their massive and diverse cytokine release, these cells also work as effectors in various contexts thanks to their cytotoxic potential. In this Review, we focused on iNKT cell cytotoxicity; we provide an overview of iNKT cell subsets, their activation cues, the mechanisms of iNKT cell cytotoxicity, the specific roles and outcomes of this activity in various contexts, and how iNKT killing functions are currently activated in cancer immunotherapies. Finally, we discuss the future perspectives for the better understanding and potential uses of iNKT cell killing functions in tumor immunosurveillance.

Díaz-Basabe, A., Strati, F., Facciotti, F. (2020). License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(11), 1-17 [10.3390/ijms21113909].

License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity

Strati F;Facciotti F
Ultimo
2020

Abstract

Invariant Natural Killer T (iNKT) cells are a non-conventional, innate-like, T cell population that recognize lipid antigens presented by the cluster of differentiation (CD)1d molecule. Although iNKT cells are mostly known for mediating several immune responses due to their massive and diverse cytokine release, these cells also work as effectors in various contexts thanks to their cytotoxic potential. In this Review, we focused on iNKT cell cytotoxicity; we provide an overview of iNKT cell subsets, their activation cues, the mechanisms of iNKT cell cytotoxicity, the specific roles and outcomes of this activity in various contexts, and how iNKT killing functions are currently activated in cancer immunotherapies. Finally, we discuss the future perspectives for the better understanding and potential uses of iNKT cell killing functions in tumor immunosurveillance.
Articolo in rivista - Review Essay
iNKT; cytotoxicity; cancer; infections; CD1d
English
2020
21
11
1
17
3909
open
Díaz-Basabe, A., Strati, F., Facciotti, F. (2020). License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(11), 1-17 [10.3390/ijms21113909].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/335323
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