The presence of hypertension among the population with human immunodeficiency virus (HIV) has become a new threat to the health and well-being of people living with this disease, in particular, among those who received antiretroviral therapy. The estimated prevalence of high blood pressure in HIV-infected patients is significantly higher than the rate observed in HIV-uninfected subjects. The approach to the HIV-positive patient requires the assessment of individual cardiovascular risk and its consideration when designing the individualized target. On the other hand, the numerous pharmacological interactions of antiretroviral (ARV) drugs are essential elements to take into account. Serum levels of any kind of antihypertensive drugs may be influenced by the coadministration of protease inhibitors, non-nucleoside reverse transcriptase inhibitor, or other antiretroviral. Similarly, plasma concentrations of antiretroviral drugs can be increased by the concomitant use of calcium channel blockers or diuretics. In this regard, the treatment of high blood pressure in HIV patients should be preferentially based on ACE inhibitors or thiazide/thiazide-like diuretics or their combination.

Robles, N., Fici, F., Valladares, J., Grassi, G. (2021). Antiretroviral Treatment and Antihypertensive Therapy. CURRENT PHARMACEUTICAL DESIGN, 27(40), 4116-4124 [10.2174/1381612827666210810090805].

Antiretroviral Treatment and Antihypertensive Therapy

Grassi, Guido
Ultimo
2021

Abstract

The presence of hypertension among the population with human immunodeficiency virus (HIV) has become a new threat to the health and well-being of people living with this disease, in particular, among those who received antiretroviral therapy. The estimated prevalence of high blood pressure in HIV-infected patients is significantly higher than the rate observed in HIV-uninfected subjects. The approach to the HIV-positive patient requires the assessment of individual cardiovascular risk and its consideration when designing the individualized target. On the other hand, the numerous pharmacological interactions of antiretroviral (ARV) drugs are essential elements to take into account. Serum levels of any kind of antihypertensive drugs may be influenced by the coadministration of protease inhibitors, non-nucleoside reverse transcriptase inhibitor, or other antiretroviral. Similarly, plasma concentrations of antiretroviral drugs can be increased by the concomitant use of calcium channel blockers or diuretics. In this regard, the treatment of high blood pressure in HIV patients should be preferentially based on ACE inhibitors or thiazide/thiazide-like diuretics or their combination.
Articolo in rivista - Review Essay
Antihypertensive treatment; Antiretroviral; Cardiovascular disease; HIV infection; Hypertension; Interactions;
English
9-ago-2021
2021
27
40
4116
4124
none
Robles, N., Fici, F., Valladares, J., Grassi, G. (2021). Antiretroviral Treatment and Antihypertensive Therapy. CURRENT PHARMACEUTICAL DESIGN, 27(40), 4116-4124 [10.2174/1381612827666210810090805].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/334921
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