Purpose of our study was to assess the prevalence of hypertension mediated organ damage (HMOD) in healthy subjects with high-normal Blood Pressure (BP) comparing them with subjects with BP values that are considered normal (<130/85 mmHg) or indicative of hypertension (≥140/90 mmHg). Seven hundred fifty-five otherwise healthy subjects were included. HMOD was evaluated as pulse wave velocity (PWV), left ventricular mass index (LVMI), and carotid intima-media thickness (IMT) and plaque. When subjects were classified according to BP levels we found that the high-normal BP group showed intermediate values of PWV and higher values of IMT. This corresponds to intermediate prevalence of arterial stiffness, while there were no differences for increased IMT or carotid plaque. No subjects showed left ventricular hypertrophy. At multivariable analysis, the odds of having arterial stiffness or carotid HMOD in the high-normal group resulted not different to the normal group. In conclusion, in our otherwise healthy population, high-normal BP values were not related to aortic, carotid or cardiac HMOD.

Maloberti, A., Rebora, P., Occhino, G., Alloni, M., Musca, F., Belli, O., et al. (2022). Prevalence of hypertension mediated organ damage in subjects with high-normal blood pressure without known hypertension as well as cardiovascular and kidney disease. JOURNAL OF HUMAN HYPERTENSION, 36(7), 610-616 [10.1038/s41371-021-00604-6].

Prevalence of hypertension mediated organ damage in subjects with high-normal blood pressure without known hypertension as well as cardiovascular and kidney disease

Maloberti, Alessandro
;
Rebora, Paola;Occhino, Giuseppe;Alloni, Marta;Occhi, Lucia;De Chiara, Benedetta;Moreo, Antonella;Valsecchi, Maria Grazia;Giannattasio, Cristina
2022

Abstract

Purpose of our study was to assess the prevalence of hypertension mediated organ damage (HMOD) in healthy subjects with high-normal Blood Pressure (BP) comparing them with subjects with BP values that are considered normal (<130/85 mmHg) or indicative of hypertension (≥140/90 mmHg). Seven hundred fifty-five otherwise healthy subjects were included. HMOD was evaluated as pulse wave velocity (PWV), left ventricular mass index (LVMI), and carotid intima-media thickness (IMT) and plaque. When subjects were classified according to BP levels we found that the high-normal BP group showed intermediate values of PWV and higher values of IMT. This corresponds to intermediate prevalence of arterial stiffness, while there were no differences for increased IMT or carotid plaque. No subjects showed left ventricular hypertrophy. At multivariable analysis, the odds of having arterial stiffness or carotid HMOD in the high-normal group resulted not different to the normal group. In conclusion, in our otherwise healthy population, high-normal BP values were not related to aortic, carotid or cardiac HMOD.
Articolo in rivista - Articolo scientifico
arterial hypertenson, organ damage
English
7-set-2021
2022
36
7
610
616
none
Maloberti, A., Rebora, P., Occhino, G., Alloni, M., Musca, F., Belli, O., et al. (2022). Prevalence of hypertension mediated organ damage in subjects with high-normal blood pressure without known hypertension as well as cardiovascular and kidney disease. JOURNAL OF HUMAN HYPERTENSION, 36(7), 610-616 [10.1038/s41371-021-00604-6].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/332314
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