A total of 44 preterm fetal lambs at great risk of developing respiratory failure were delivered by Cesarean section, and were then managed on conventional mechanical pulmonary ventilation. Fifteen animals initially fared well, and 14 of these were long term survivors. Twenty-nine other lambs showed a progressive deterioration in arterial blood gases within 30 minutes of delivery, of which 10 lambs were continued on mechanical pulmonary ventilation (20% survival), while the remaining 19 lambs were placed on an extracorporeal membrane lung respiratory assist (79% survival). Extracorporeal membrane lung bypass rapidly corrected arterial blood gas values, and permitted the use of high levels of CPAP instead of the continuation of mechanical pulmonary ventilation at high peak airway pressures. Improvement in lung function was gradual, and predictable. Early institution of extracorporeal respiratory assist using a membrane artificial lung rapidly corrected arterial blood gas values and significantly improved on neonate survival.

Fumagalli, R., Kolobow, T., Arosio, P., Chen, V., Buckhold, D., Pierce, J. (1986). Successful treatment of experimental neonatal respiratory failure using extracorporeal membrane lung assist. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 9(6), 427-432 [10.1177/039139888600900613].

Successful treatment of experimental neonatal respiratory failure using extracorporeal membrane lung assist

FUMAGALLI, ROBERTO;
1986

Abstract

A total of 44 preterm fetal lambs at great risk of developing respiratory failure were delivered by Cesarean section, and were then managed on conventional mechanical pulmonary ventilation. Fifteen animals initially fared well, and 14 of these were long term survivors. Twenty-nine other lambs showed a progressive deterioration in arterial blood gases within 30 minutes of delivery, of which 10 lambs were continued on mechanical pulmonary ventilation (20% survival), while the remaining 19 lambs were placed on an extracorporeal membrane lung respiratory assist (79% survival). Extracorporeal membrane lung bypass rapidly corrected arterial blood gas values, and permitted the use of high levels of CPAP instead of the continuation of mechanical pulmonary ventilation at high peak airway pressures. Improvement in lung function was gradual, and predictable. Early institution of extracorporeal respiratory assist using a membrane artificial lung rapidly corrected arterial blood gas values and significantly improved on neonate survival.
Articolo in rivista - Articolo scientifico
Animals; Animals, Newborn; Extracorporeal Circulation; Sheep; Respiratory Distress Syndrome, Newborn; Infant, Newborn; Respiration, Artificial; Oxygenators, Membrane
English
1986
9
6
427
432
none
Fumagalli, R., Kolobow, T., Arosio, P., Chen, V., Buckhold, D., Pierce, J. (1986). Successful treatment of experimental neonatal respiratory failure using extracorporeal membrane lung assist. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 9(6), 427-432 [10.1177/039139888600900613].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/33216
Citazioni
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
Social impact