Defects in mitochondrial enzymes have been found not only in substantia nigra, but also in platelets from Parkinson's Disease (PD) patients, suggesting a systemic impairment of energy metabolism. Since platelets present an energy-dependent glutamate uptake similar to that described in central nervous system, glutamate uptake was determined in platelets from 34PD patients and 21 age-related normal controls, as Na+-dependent [3H]glutamate influx; glutamate level was also analyzed by reverse-phase HPLC. A 50% reduction of glutamate uptake (p < 0.001) was observed in idiopathic PD patients, respect to controls and secondary parkinsonian syndromes. The decrease correlated with the severity of PD, measured by the UPDRS (r = -0.54; P < 0.05). Glutamate level was increased in platelets of PD patients, but was not correlated to the uptake decrease. Both phoenomena may be explained by the modifications of mitochondrial enzymes described in platelets, which could be used as a peripheral model of glutamatergic function in PD

Ferrarese, C., Zoia, C., Pecora, N., Piolti, R., Frigo, M., Bianchi, G., et al. (1999). Reduced platelet glutamate uptake in Parkinson's disease. JOURNAL OF NEURAL TRANSMISSION, 106(7-8), 685-692 [10.1007/s007020050189].

Reduced platelet glutamate uptake in Parkinson's disease

FERRARESE, CARLO;ZOIA, CHIARA PAOLA;PECORA, NICOLETTA;FRIGO, MARTA;BIANCHI, GIANLUIGI;SALA, GESSICA;
1999

Abstract

Defects in mitochondrial enzymes have been found not only in substantia nigra, but also in platelets from Parkinson's Disease (PD) patients, suggesting a systemic impairment of energy metabolism. Since platelets present an energy-dependent glutamate uptake similar to that described in central nervous system, glutamate uptake was determined in platelets from 34PD patients and 21 age-related normal controls, as Na+-dependent [3H]glutamate influx; glutamate level was also analyzed by reverse-phase HPLC. A 50% reduction of glutamate uptake (p < 0.001) was observed in idiopathic PD patients, respect to controls and secondary parkinsonian syndromes. The decrease correlated with the severity of PD, measured by the UPDRS (r = -0.54; P < 0.05). Glutamate level was increased in platelets of PD patients, but was not correlated to the uptake decrease. Both phoenomena may be explained by the modifications of mitochondrial enzymes described in platelets, which could be used as a peripheral model of glutamatergic function in PD
Articolo in rivista - Articolo scientifico
Blood Platelets; Analysis of Variance; Parkinson Disease; Humans; Glutamic Acid; Case-Control Studies; Energy Metabolism; Male; Female
English
685
692
8
Ferrarese, C., Zoia, C., Pecora, N., Piolti, R., Frigo, M., Bianchi, G., et al. (1999). Reduced platelet glutamate uptake in Parkinson's disease. JOURNAL OF NEURAL TRANSMISSION, 106(7-8), 685-692 [10.1007/s007020050189].
Ferrarese, C; Zoia, C; Pecora, N; Piolti, R; Frigo, M; Bianchi, G; Sala, G; Begni, B; Riva, R; Frattola, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/33186
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