Detection of target and non-target substances and their characterization in complex samples is a challenging task. Here we demonstrate that coating the electron ionization (EI) ion source of an LC-MS system with a sol-gel ceramic film can drastically improve the detection of high-molecular weight and high-boiling analytes. A new ion source coated with a ceramic material was developed and tested with a mixture of polycyclic aromatic hydrocarbons (PAH) with an increasing number of rings. Comparison of the results obtained with those for an uncoated stainless steel (SS) ion source shows a dramatic improvement in the MS signals, with a nearly 40-fold increase of the signal-to-noise ratio. We also demonstrate the ability of the new system to produce excellent chromatographic profiles for hard-to-detect hormones.

Magrini, L., Famiglini, G., Palma, P., Termopoli, V., Cappiello, A. (2016). Boosting the Detection Potential of Liquid Chromatography-Electron Ionization Mass Spectrometry Using a Ceramic Coated Ion Source. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 27(1), 153-160 [10.1007/s13361-015-1257-0].

Boosting the Detection Potential of Liquid Chromatography-Electron Ionization Mass Spectrometry Using a Ceramic Coated Ion Source

TERMOPOLI, VERONICA;
2016

Abstract

Detection of target and non-target substances and their characterization in complex samples is a challenging task. Here we demonstrate that coating the electron ionization (EI) ion source of an LC-MS system with a sol-gel ceramic film can drastically improve the detection of high-molecular weight and high-boiling analytes. A new ion source coated with a ceramic material was developed and tested with a mixture of polycyclic aromatic hydrocarbons (PAH) with an increasing number of rings. Comparison of the results obtained with those for an uncoated stainless steel (SS) ion source shows a dramatic improvement in the MS signals, with a nearly 40-fold increase of the signal-to-noise ratio. We also demonstrate the ability of the new system to produce excellent chromatographic profiles for hard-to-detect hormones.
Articolo in rivista - Articolo scientifico
LC-MS; Mass spectrometry; EI; Electron ionization; Ion source; Ceramic coating; Inert surface; PAH; Polycyclic aromatic hydrocarbons; Hormones; Sterols
English
8-set-2015
2016
27
1
153
160
reserved
Magrini, L., Famiglini, G., Palma, P., Termopoli, V., Cappiello, A. (2016). Boosting the Detection Potential of Liquid Chromatography-Electron Ionization Mass Spectrometry Using a Ceramic Coated Ion Source. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 27(1), 153-160 [10.1007/s13361-015-1257-0].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/331750
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