A chemometric optimization of the Ru3(CO)12 catalysed deoxygenation of 2-nitrostilbene to 2-phenylindole was carried out. The effects of temperature, CO pressure, amounts of catalyst and substrate on conversion and selectivity were examined by factorial design/response surface methods. The conversion was found to increase on increasing the temperature and decreasing the CO pressure, it assumed a minimum value for medium amounts of catalyst and was almost independent of the amount of substrate. These results were also confirmed using a learning system and were used to develop a mechanism for the reaction. The data suggest two different mechanisms: one based on a Ru(CO)5 catalysed process and another one based on a Ru3(CO)12 catalysed process, which are first and zero order with respect to the substrate, respectively
Crotti, C., Cenini, S., Todeschini, R., & Tollari, S. (1991). Chemometric optimization of the ruthenium carbonyl catalyzed cyclization of 2-nitrostilbene to 2-phenylindole. JOURNAL OF THE CHEMICAL SOCIETY. FARADAY TRANSACTIONS, 87, 2811-2820.
Citazione: | Crotti, C., Cenini, S., Todeschini, R., & Tollari, S. (1991). Chemometric optimization of the ruthenium carbonyl catalyzed cyclization of 2-nitrostilbene to 2-phenylindole. JOURNAL OF THE CHEMICAL SOCIETY. FARADAY TRANSACTIONS, 87, 2811-2820. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Chemometric optimization of the ruthenium carbonyl catalyzed cyclization of 2-nitrostilbene to 2-phenylindole |
Autori: | Crotti, C; Cenini, S; Todeschini, R; Tollari, S |
Autori: | |
Data di pubblicazione: | 1991 |
Lingua: | English |
Rivista: | JOURNAL OF THE CHEMICAL SOCIETY. FARADAY TRANSACTIONS |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/ft9918702811 |
Appare nelle tipologie: | 01 - Articolo su rivista |