Both visuo-spatial neglect and visual extinction may occur following right-brain damage. So far, studies on brain-damaged patients have not provided definite evidence about which lesion patterns may lead to the association or dissociation of these deficits. This study was set out to address this issue using Intracranial Electrical Stimulation (IES) in a group of nine patients affected by refractory epilepsy. Cerebral regions associated with visuo-spatial neglect and visual extinction were stimulated, including the right frontal, temporal, and posterior parietal areas. During IES, patients with intracranial implantation involving at least one of these cortical regions were administered with a manual line bisection task (N = 9) to assess visuo-spatial neglect, and a computerized task (N = 8) assessing visual extinction. Results showed that parietal IES induced a rightward bias at the manual bisection task, together with a general improvement in reaction times at bilateral and unilateral visual stimuli detection at the extinction task. The occurrence of visual extinction did not vary across stimulations. By adopting a complementary approach to anatomo-clinical correlation studies, our work corroborates the notion that lesions to the right inferior parietal lobule play a pivotal role in the pathogenesis of visuo-spatial neglect. Importantly, our results also suggest that temporarily interfering with the activity of this region is not sufficient per se to generate visual extinction, which instead may involve a broader and/or different network, possibly extending beyond the cerebral regions considered here, posing important theoretical and clinical implications.

Salvato, G., Peviani, V., Scarpa, P., Francione, S., Castana, L., Gallace, A., et al. (2021). Investigating visuo-spatial neglect and visual extinction during intracranial electrical stimulations: the role of the right inferior parietal cortex. NEUROPSYCHOLOGIA, 162(12 November 2021) [10.1016/j.neuropsychologia.2021.108049].

Investigating visuo-spatial neglect and visual extinction during intracranial electrical stimulations: the role of the right inferior parietal cortex

Scarpa, Pina;Gallace, Alberto
Membro del Collaboration Group
;
Bricolo, Emanuela
Membro del Collaboration Group
;
Vallar, Giuseppe
Penultimo
Membro del Collaboration Group
;
2021

Abstract

Both visuo-spatial neglect and visual extinction may occur following right-brain damage. So far, studies on brain-damaged patients have not provided definite evidence about which lesion patterns may lead to the association or dissociation of these deficits. This study was set out to address this issue using Intracranial Electrical Stimulation (IES) in a group of nine patients affected by refractory epilepsy. Cerebral regions associated with visuo-spatial neglect and visual extinction were stimulated, including the right frontal, temporal, and posterior parietal areas. During IES, patients with intracranial implantation involving at least one of these cortical regions were administered with a manual line bisection task (N = 9) to assess visuo-spatial neglect, and a computerized task (N = 8) assessing visual extinction. Results showed that parietal IES induced a rightward bias at the manual bisection task, together with a general improvement in reaction times at bilateral and unilateral visual stimuli detection at the extinction task. The occurrence of visual extinction did not vary across stimulations. By adopting a complementary approach to anatomo-clinical correlation studies, our work corroborates the notion that lesions to the right inferior parietal lobule play a pivotal role in the pathogenesis of visuo-spatial neglect. Importantly, our results also suggest that temporarily interfering with the activity of this region is not sufficient per se to generate visual extinction, which instead may involve a broader and/or different network, possibly extending beyond the cerebral regions considered here, posing important theoretical and clinical implications.
Articolo in rivista - Articolo scientifico
Extinction to double simultaneous stimulation; Intracranial electrical stimulation; Visuo-spatial neglect;
English
5-ott-2021
2021
162
12 November 2021
108049
none
Salvato, G., Peviani, V., Scarpa, P., Francione, S., Castana, L., Gallace, A., et al. (2021). Investigating visuo-spatial neglect and visual extinction during intracranial electrical stimulations: the role of the right inferior parietal cortex. NEUROPSYCHOLOGIA, 162(12 November 2021) [10.1016/j.neuropsychologia.2021.108049].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/330685
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