Surgical treatment of elderly patients with meningioma is has proved to be safe, especially when patients are selected using dedicated surgical scores. These scores take into account tumor size, edema, location and patient’s co-morbidities. Neuropsychological functioning (NPF) of this kind of patients has been poorly studied in literature and it is not taken into account by these scores. Aim of our study was to describe the long-term outcome in terms of NPF of elderly patients undergoing surgery. Patients older than 70 years of age affected by intracranial meningioma and selected with the Clinical-Radiological Grading Score were included in our study. Neuropsychological testing was performed using a dedicated battery of tests before surgery, 3 and 12 months after surgery. Clinical, neurological and radiological outcomes were studied as well. Forty-one patients with a median age of 74 years were included in this study. Preoperatively only 1/41 patients showed a normal NPF with all tests scoring normally. Four out of 39 patients showed a complete neuropsychological recovery after 3 months; while 10/37 patients had a complete recovery after 12 months. NPF showed a trend of progressive improvement after surgery. Our study is the first experience reported in literature describing a long term follow-up in elderly patients after surgery for intracranial meningioma. In our series, surgery determined an improvement of NPF over time; especially with a low complication rate related to the selection of patients obtained through the CRGS. Further studies need to be performed in order to understand how brain edema, tumor size, volume and tumor location affect NPF in both short and long term.

Di Cristofori, A., Zarino, B., Bertani, G., Locatelli, M., Rampini, P., Carrabba, G., et al. (2018). Surgery in elderly patients with intracranial meningioma : neuropsychological functioning during a long term follow-up. JOURNAL OF NEURO-ONCOLOGY, 137(3), 611-619 [10.1007/s11060-018-2754-3].

Surgery in elderly patients with intracranial meningioma : neuropsychological functioning during a long term follow-up

Di Cristofori, Andrea
;
Carrabba, Giorgio;
2018

Abstract

Surgical treatment of elderly patients with meningioma is has proved to be safe, especially when patients are selected using dedicated surgical scores. These scores take into account tumor size, edema, location and patient’s co-morbidities. Neuropsychological functioning (NPF) of this kind of patients has been poorly studied in literature and it is not taken into account by these scores. Aim of our study was to describe the long-term outcome in terms of NPF of elderly patients undergoing surgery. Patients older than 70 years of age affected by intracranial meningioma and selected with the Clinical-Radiological Grading Score were included in our study. Neuropsychological testing was performed using a dedicated battery of tests before surgery, 3 and 12 months after surgery. Clinical, neurological and radiological outcomes were studied as well. Forty-one patients with a median age of 74 years were included in this study. Preoperatively only 1/41 patients showed a normal NPF with all tests scoring normally. Four out of 39 patients showed a complete neuropsychological recovery after 3 months; while 10/37 patients had a complete recovery after 12 months. NPF showed a trend of progressive improvement after surgery. Our study is the first experience reported in literature describing a long term follow-up in elderly patients after surgery for intracranial meningioma. In our series, surgery determined an improvement of NPF over time; especially with a low complication rate related to the selection of patients obtained through the CRGS. Further studies need to be performed in order to understand how brain edema, tumor size, volume and tumor location affect NPF in both short and long term.
Articolo in rivista - Articolo scientifico
CRGS; Elderly meningioma; Elderly neurosurgery; Meningioma; Meningioma surgery outcome; Neuropsychology;
English
2018
137
3
611
619
reserved
Di Cristofori, A., Zarino, B., Bertani, G., Locatelli, M., Rampini, P., Carrabba, G., et al. (2018). Surgery in elderly patients with intracranial meningioma : neuropsychological functioning during a long term follow-up. JOURNAL OF NEURO-ONCOLOGY, 137(3), 611-619 [10.1007/s11060-018-2754-3].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/329364
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