Functional or secondary tricuspid regurgitation (FTR) is a progressive disease with a signifi cant negative impact on patient morbidity and mortality. Recently, atrial fi brillation (AF) has been recognized as a cause of FTR (with/without coexisting functional mitral regurgitation) by promoting right atrial (RA) remodeling and secondary tricuspid valve (TV) annulus dilation, even in the absence of right ventricular (RV) dilation or dysfunction. This distinct form of FTR has been called “atriogenic” or “atrial”. Recent evidence suggests that the RA is an important player in FTR pathophysiology not only for patients with AF, but also for those in sinus rhythm. Preliminary reports on atrial FTR show that cardioversion with documented maintenance of sinus rhythm promotes TV annulus and RA reverse remodeling and may signifi cantly reduce FTR severity at follow-up. Large-scale studies on the prognostic benefi ts of rhythm vs rate-control strategy in atrial FTR patients are needed to substantiate specifi c guidelines indications for this subset of patients.

Florescu, D., Figliozzi, S., Guta, A., Vicini, S., Tomaselli, M., Târtea, G., et al. (2021). Atrial functional tricuspid regurgitation: a novel and underappreciated clinical entity. ROMANIAN JOURNAL OF CARDIOLOGY, 31(1), 27-35 [10.47803/rjc.2021.31.1.27].

Atrial functional tricuspid regurgitation: a novel and underappreciated clinical entity

Vicini, Stefano;Tomaselli, Michele;Parati, Gianfranco;Badano, Luigi;Muraru, Denisa
2021

Abstract

Functional or secondary tricuspid regurgitation (FTR) is a progressive disease with a signifi cant negative impact on patient morbidity and mortality. Recently, atrial fi brillation (AF) has been recognized as a cause of FTR (with/without coexisting functional mitral regurgitation) by promoting right atrial (RA) remodeling and secondary tricuspid valve (TV) annulus dilation, even in the absence of right ventricular (RV) dilation or dysfunction. This distinct form of FTR has been called “atriogenic” or “atrial”. Recent evidence suggests that the RA is an important player in FTR pathophysiology not only for patients with AF, but also for those in sinus rhythm. Preliminary reports on atrial FTR show that cardioversion with documented maintenance of sinus rhythm promotes TV annulus and RA reverse remodeling and may signifi cantly reduce FTR severity at follow-up. Large-scale studies on the prognostic benefi ts of rhythm vs rate-control strategy in atrial FTR patients are needed to substantiate specifi c guidelines indications for this subset of patients.
Articolo in rivista - Articolo scientifico
Scientifica
tricuspid regurgitation, atrial fibrillation, pathophysiology
English
Florescu, D., Figliozzi, S., Guta, A., Vicini, S., Tomaselli, M., Târtea, G., et al. (2021). Atrial functional tricuspid regurgitation: a novel and underappreciated clinical entity. ROMANIAN JOURNAL OF CARDIOLOGY, 31(1), 27-35 [10.47803/rjc.2021.31.1.27].
Florescu, D; Figliozzi, S; Guta, A; Vicini, S; Tomaselli, M; Târtea, G; Istrătoaie, O; Parati, G; Badano, L; Muraru, D
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/329324
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