The pulmonary effects of hyperventilation following infusion of sodium salicylate into the cisterna magna was studied in 16 spontaneously breathing adult sheep. We found a fall in PaO2, a decrease in the static compliance of the respiratory system, abnormal chest roentgenographic films, and grossly abnormal lungs following 3.5 to 13 h of hyperventilation. A control group of 15 sheep (10 sheep similarly injected with sodium salicylate, but then sedated and paralyzed and ventilated at normal tidal volume and respiratory rate on a mechanical ventilator, and 5 sheep infused with saline alone and breathing spontaneously) showed no pulmonary or arterial blood gas abnormalities. We conclude that prolonged hyperventilation under the conditions of this experiment precipitated events that resulted in acute lung injury.

Mascheroni, D., Kolobow, T., Fumagalli, R., Moretti, M., Chen, V., Buckhold, D. (1988). Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. INTENSIVE CARE MEDICINE, 15(1), 8-14 [10.1007/BF00255628].

Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study

FUMAGALLI, ROBERTO;
1988

Abstract

The pulmonary effects of hyperventilation following infusion of sodium salicylate into the cisterna magna was studied in 16 spontaneously breathing adult sheep. We found a fall in PaO2, a decrease in the static compliance of the respiratory system, abnormal chest roentgenographic films, and grossly abnormal lungs following 3.5 to 13 h of hyperventilation. A control group of 15 sheep (10 sheep similarly injected with sodium salicylate, but then sedated and paralyzed and ventilated at normal tidal volume and respiratory rate on a mechanical ventilator, and 5 sheep infused with saline alone and breathing spontaneously) showed no pulmonary or arterial blood gas abnormalities. We conclude that prolonged hyperventilation under the conditions of this experiment precipitated events that resulted in acute lung injury.
Articolo in rivista - Articolo scientifico
Animals; Respiratory Insufficiency; Sheep; Sodium Salicylate; Hyperventilation; Respiration, Artificial; Lung Volume Measurements
English
1988
15
1
8
14
none
Mascheroni, D., Kolobow, T., Fumagalli, R., Moretti, M., Chen, V., Buckhold, D. (1988). Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. INTENSIVE CARE MEDICINE, 15(1), 8-14 [10.1007/BF00255628].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/32887
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