The interaction between copper-zinc superoxide dismutase (Cu-Zn SOD) and anthracycline antitumour drugs (doxorubicin and 4′-epidoxorubicin) has been investigated by e.s.r. spectroscopy. The Cu2+ centres within the enzyme structure are available for anthracycline coordination in a way similar to that observed for copper-anthracycline derivatives when CuCl2 was used and at high r values (where r is the anthracycline/Cu2+ molar ratio). The amount of copper extracted by the drug increases as the protein concentration decreases, and several stacked anthracycline units are found to bind to one Cu2+ centre.
Malatesta, V., Morazzoni, F., Pellicciaribollini, L., Scotti, R. (1987). THE INTERACTION BETWEEN SUPEROXIDE-DISMUTASE AND DOXORUBICIN - AN ELECTRON-SPIN-RESONANCE APPROACH. JOURNAL OF THE CHEMICAL SOCIETY. FARADAY TRANSACTIONS I, 83(12), 3669-3673 [10.1039/f19878303669].
THE INTERACTION BETWEEN SUPEROXIDE-DISMUTASE AND DOXORUBICIN - AN ELECTRON-SPIN-RESONANCE APPROACH
MORAZZONI, FRANCA;SCOTTI, ROBERTO
1987
Abstract
The interaction between copper-zinc superoxide dismutase (Cu-Zn SOD) and anthracycline antitumour drugs (doxorubicin and 4′-epidoxorubicin) has been investigated by e.s.r. spectroscopy. The Cu2+ centres within the enzyme structure are available for anthracycline coordination in a way similar to that observed for copper-anthracycline derivatives when CuCl2 was used and at high r values (where r is the anthracycline/Cu2+ molar ratio). The amount of copper extracted by the drug increases as the protein concentration decreases, and several stacked anthracycline units are found to bind to one Cu2+ centre.
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