The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months.

Provenzi, L., Mambretti, F., Villa, M., Grumi, S., Citterio, A., Bertazzoli, E., et al. (2021). Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months. SCIENTIFIC REPORTS, 11(1 (December 2021)) [10.1038/s41598-021-95053-z].

Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months

Provenzi L.
;
Nacinovich R.;
2021

Abstract

The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months.
Articolo in rivista - Articolo scientifico
Adult; Female; Humans; Infant, Newborn; Longitudinal Studies; Male; Pregnancy; SARS-CoV-2; COVID-19; DNA Methylation; Pandemics; Prenatal Exposure Delayed Effects; Serotonin Plasma Membrane Transport Proteins; Stress, Physiological
English
2-ago-2021
2021
11
1 (December 2021)
15658
open
Provenzi, L., Mambretti, F., Villa, M., Grumi, S., Citterio, A., Bertazzoli, E., et al. (2021). Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months. SCIENTIFIC REPORTS, 11(1 (December 2021)) [10.1038/s41598-021-95053-z].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/325260
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