Glioblastoma (GBM) is a particularly challenging brain tumor characterized by a het-erogeneous, complex, and multicellular microenvironment, which represents a strategic network for treatment escape. Furthermore, the presence of GBM stem cells (GSCs) seems to contribute to GBM recurrence after surgery, and chemo-and/or radiotherapy. In this context, intercellular communication modalities play key roles in driving GBM therapy resistance. The presence of tunneling nanotubes (TNTs), long membranous open-ended channels connecting distant cells, has been observed in several types of cancer, where they emerge to steer a more malignant phenotype. Here, we discuss the current knowledge about the formation of TNTs between different cellular types in the GBM microenvironment and their potential role in tumor progression and recurrence. Particularly, we highlight two prospective strategies targeting TNTs as possible therapeutics: (i) the inhibition of TNT formation and (ii) a boost in drug delivery between cells through these channels. The latter may require future studies to design drug delivery systems that are exchangeable through TNTs, thus allowing for access to distant tumor niches that are involved in tumor immune escape, maintenance of GSC plasticity, and increases in metastatic potential.

Taiarol, L., Formicola, B., Fagioli, S., Sierri, G., D'Aloia, A., Kravicz, M., et al. (2021). The 3.0 cell communication: New insights in the usefulness of tunneling nanotubes for glioblastoma treatment. CANCERS, 13(16) [10.3390/cancers13164001].

The 3.0 cell communication: New insights in the usefulness of tunneling nanotubes for glioblastoma treatment

Taiarol L.
Primo
;
Formicola B.;D'aloia A.;Kravicz M.;Ceriani M.;Re F.
Ultimo
2021

Abstract

Glioblastoma (GBM) is a particularly challenging brain tumor characterized by a het-erogeneous, complex, and multicellular microenvironment, which represents a strategic network for treatment escape. Furthermore, the presence of GBM stem cells (GSCs) seems to contribute to GBM recurrence after surgery, and chemo-and/or radiotherapy. In this context, intercellular communication modalities play key roles in driving GBM therapy resistance. The presence of tunneling nanotubes (TNTs), long membranous open-ended channels connecting distant cells, has been observed in several types of cancer, where they emerge to steer a more malignant phenotype. Here, we discuss the current knowledge about the formation of TNTs between different cellular types in the GBM microenvironment and their potential role in tumor progression and recurrence. Particularly, we highlight two prospective strategies targeting TNTs as possible therapeutics: (i) the inhibition of TNT formation and (ii) a boost in drug delivery between cells through these channels. The latter may require future studies to design drug delivery systems that are exchangeable through TNTs, thus allowing for access to distant tumor niches that are involved in tumor immune escape, maintenance of GSC plasticity, and increases in metastatic potential.
Articolo in rivista - Review Essay
Drug deliv-ery; Glioblastoma; Nanoparticles; Stem cells; Tumor microenvironment; Tunneling nanotubes;
English
8-ago-2021
2021
13
16
4001
open
Taiarol, L., Formicola, B., Fagioli, S., Sierri, G., D'Aloia, A., Kravicz, M., et al. (2021). The 3.0 cell communication: New insights in the usefulness of tunneling nanotubes for glioblastoma treatment. CANCERS, 13(16) [10.3390/cancers13164001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/324631
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