Gelatin is a costless polypeptide material of natural origin, able to form hydrogels that are potentially useful in biomaterial scaffold design for drug delivery, cell cultures, and tissue engineering. However, gelatin hydrogels are unstable at physiological conditions, losing their features only after a few minutes at 37 °C. Accordingly, treatments to address this issue are of great interest. In the present work, we propose for the first time the use of bi- and trifunctional tetrazoles, most of them unknown to date, for photoinduced gelatin cross-linking towards the production of physiologically stable hydrogels. Indeed, after UV-B irradiation, aryl tetrazoles generate a nitrilimine intermediate that is reactive towards different functionalities, some of them constitutively present in the amino acid side chains of gelatin. The efficacy of the treatment strictly depends on the structure of the cross-linking agent used, and substantial improved stability was observed by switching from bifunctional to trifunctional cross-linker

Vaghi, L., Monti, M., Marelli, M., Motto, E., Papagni, A., Cipolla, L. (2021). Photoinduced Porcine Gelatin Cross-Linking by Homobi- and Homotrifunctional Tetrazoles. GELS, 7(3 (September 2021)) [10.3390/gels7030124].

Photoinduced Porcine Gelatin Cross-Linking by Homobi- and Homotrifunctional Tetrazoles

Vaghi, Luca
Primo
;
Monti, Mauro
Secondo
;
Papagni, Antonio
Penultimo
;
Cipolla, Laura
Ultimo
2021

Abstract

Gelatin is a costless polypeptide material of natural origin, able to form hydrogels that are potentially useful in biomaterial scaffold design for drug delivery, cell cultures, and tissue engineering. However, gelatin hydrogels are unstable at physiological conditions, losing their features only after a few minutes at 37 °C. Accordingly, treatments to address this issue are of great interest. In the present work, we propose for the first time the use of bi- and trifunctional tetrazoles, most of them unknown to date, for photoinduced gelatin cross-linking towards the production of physiologically stable hydrogels. Indeed, after UV-B irradiation, aryl tetrazoles generate a nitrilimine intermediate that is reactive towards different functionalities, some of them constitutively present in the amino acid side chains of gelatin. The efficacy of the treatment strictly depends on the structure of the cross-linking agent used, and substantial improved stability was observed by switching from bifunctional to trifunctional cross-linker
Articolo in rivista - Articolo scientifico
gelatin; hydrogel; photochemistry; tetrazoles; nitrilimine; chemical cross-linking; natural polymers
English
Gold Open Access• Green Open Access
Vaghi, L., Monti, M., Marelli, M., Motto, E., Papagni, A., Cipolla, L. (2021). Photoinduced Porcine Gelatin Cross-Linking by Homobi- and Homotrifunctional Tetrazoles. GELS, 7(3 (September 2021)) [10.3390/gels7030124].
Vaghi, L; Monti, M; Marelli, M; Motto, E; Papagni, A; Cipolla, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/324447
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