The Ah receptor (AhR) is a ligand-dependent transcription factor that call be activated by structurally diverse synthetic and naturally-occurring chemicals. Although a significant amount of information is available with respect to the planar aromatic hydrocarbon AhR ligands, the actual spectrum of chemicals that can bind to and activate the AhR is only now being elucidated. In addition, the lack of information regarding the actual three-dimensional structure of the AhR ligand binding domain (LBD) has hindered detailed analysis of the molecular mechanisms by which these ligands bind to an active AhR signal transduction. In this review we describe the current state of knowledge with respect to naturally occurring AhR ligands and present and discuss the first theoretical model of the AhR LBD based on crystal structures of homologous PAS family members. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Denison, M., Pandini, A., Nagy, S., Baldwin, E., Bonati, L. (2002). Ligand binding and activation of the Ah receptor. CHEMICO-BIOLOGICAL INTERACTIONS, 141(1-2), 3-24 [10.1016/S0009-2797(02)00063-7].

Ligand binding and activation of the Ah receptor

Bonati, L
2002

Abstract

The Ah receptor (AhR) is a ligand-dependent transcription factor that call be activated by structurally diverse synthetic and naturally-occurring chemicals. Although a significant amount of information is available with respect to the planar aromatic hydrocarbon AhR ligands, the actual spectrum of chemicals that can bind to and activate the AhR is only now being elucidated. In addition, the lack of information regarding the actual three-dimensional structure of the AhR ligand binding domain (LBD) has hindered detailed analysis of the molecular mechanisms by which these ligands bind to an active AhR signal transduction. In this review we describe the current state of knowledge with respect to naturally occurring AhR ligands and present and discuss the first theoretical model of the AhR LBD based on crystal structures of homologous PAS family members. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Articolo in rivista - Articolo scientifico
Ah receptor; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD; dioxin homology model; ligand binding domain
English
2002
141
1-2
3
24
none
Denison, M., Pandini, A., Nagy, S., Baldwin, E., Bonati, L. (2002). Ligand binding and activation of the Ah receptor. CHEMICO-BIOLOGICAL INTERACTIONS, 141(1-2), 3-24 [10.1016/S0009-2797(02)00063-7].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/3244
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