Paraganglioma is a rare tumour that originates from any paraganglia. Among extra-adrenal paraganglioma, renal hilus is a rare location. The authors report a case of a 43-year-old female who was admitted for evaluation of a renal mass detected incidentally by ultrasound imaging. Suspecting malignancy, the patient underwent radical nephrectomy. Upon macroscopic examination, the lesion was located into the renal hilus. Histological study revealed a neoplasm constituted of nests of monomorphic cuboidal cells with basophilic granular cytoplasm and round to oval nuclei. Necrosis was absent. The proliferative index (Mib-1) was very low (< 5%). Immunohistochemical examination revealed reactivity for neuron specific enolase (NSE), chromogranin A and synaptophysin. The final diagnosis was renal hilus paraganglioma. The paper shows the difficulty in diagnostic approaches to paraganglioma in this atypical site.

Pagni, F., Galbiati, E., Bono, F., Di Bella, C. (2009). Renal hilus paraganglioma: A case report and brief review. PATHOLOGICA, 101(2), 89-92.

Renal hilus paraganglioma: A case report and brief review

Pagni F.
;
Galbiati E.;Bono F.;Di Bella C.
2009

Abstract

Paraganglioma is a rare tumour that originates from any paraganglia. Among extra-adrenal paraganglioma, renal hilus is a rare location. The authors report a case of a 43-year-old female who was admitted for evaluation of a renal mass detected incidentally by ultrasound imaging. Suspecting malignancy, the patient underwent radical nephrectomy. Upon macroscopic examination, the lesion was located into the renal hilus. Histological study revealed a neoplasm constituted of nests of monomorphic cuboidal cells with basophilic granular cytoplasm and round to oval nuclei. Necrosis was absent. The proliferative index (Mib-1) was very low (< 5%). Immunohistochemical examination revealed reactivity for neuron specific enolase (NSE), chromogranin A and synaptophysin. The final diagnosis was renal hilus paraganglioma. The paper shows the difficulty in diagnostic approaches to paraganglioma in this atypical site.
No
Articolo in rivista - Articolo scientifico
Scientifica
Extraadrenal paraganglioma; Extraadrenal pheochromocytoma; Paraganglioma; Renal hilus
English
89
92
4
Pagni, F., Galbiati, E., Bono, F., Di Bella, C. (2009). Renal hilus paraganglioma: A case report and brief review. PATHOLOGICA, 101(2), 89-92.
Pagni, F; Galbiati, E; Bono, F; Di Bella, C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/324217
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