The main target of a biorefinery pretreatment process is to break down the lignin reinforced plant cell wall structure prior to enzymatic hydrolysis of polysaccharides to fermentable sugars. Various physico-chemical alterations occur in lignin during the biomass pretreatment, but effects of those structural changes on subsequent enzymatic hydrolysis have remained ambiguous. We review the reinforcing and detrimental lignin-enzyme interactions and their underlying mechanisms, and use this structure-function information to assess critical features of current and emerging pretreatment technologies. Our perspective is that truly multidisciplinary research is needed to develop pretreatments that render lignin non-inhibiting to enzymes and with high potential for further valorisation.
SIPPONEN Mika, H., Rahikainen, J., Leskinen, T., Pihlajaniemi, V., Mattinen, M., Lange, H., et al. (2017). Structural changes of lignin in biorefinery pretreatments and consequences to enzyme-lignin interactions. NORDIC PULP & PAPER RESEARCH JOURNAL, 32(4), 547-568 [10.3183/NPPRJ-2017-32-04-p550-571].
Structural changes of lignin in biorefinery pretreatments and consequences to enzyme-lignin interactions
LANGE Heiko;
2017
Abstract
The main target of a biorefinery pretreatment process is to break down the lignin reinforced plant cell wall structure prior to enzymatic hydrolysis of polysaccharides to fermentable sugars. Various physico-chemical alterations occur in lignin during the biomass pretreatment, but effects of those structural changes on subsequent enzymatic hydrolysis have remained ambiguous. We review the reinforcing and detrimental lignin-enzyme interactions and their underlying mechanisms, and use this structure-function information to assess critical features of current and emerging pretreatment technologies. Our perspective is that truly multidisciplinary research is needed to develop pretreatments that render lignin non-inhibiting to enzymes and with high potential for further valorisation.File | Dimensione | Formato | |
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