To determine the role of home blood pressure (BP) monitoring for a reproducible assessment of orthostatic hypertension (OHT) and the effectiveness of hypertension control by doxazosin. In this study, 605 medicated hypertensive outpatients were enrolled. Home BP in the sitting and standing positions was monitored in all patients in the morning and evening for 6 months. According to an open-label multicenter trial design, the patients were randomly allocated to either an intervention group that took doxazosin (1-4 mg) at bedtime or to a control group that did not receive any add-on medication. The patients were divided into deciles of orthostatic BP change as evaluated by home BP monitoring at baseline. Those in the top decile, in the lowest decile and in deciles two through eight were then assigned to the OHT group, the orthostatic hypotension group and the orthostatic normotension group, respectively. Orthostatic BP in the OHYPO group did not change, whereas that of the OHT group was markedly reduced by doxazosin (P<0.01). In the control group, classification into orthostatic BP categories using home BP monitoring was more reproducible (kappa coefficient: 0.42-0.50) than when using clinical BP (kappa coefficient: 0.13-0.24). In all groups, a reduction in the urinary albumin/creatinine ratio was significantly associated with a reduction in orthostatic BP doxazosin (P<0.001). The identification of OHT based on home BP monitoring was highly reproducible. The administration of doxazosin might control OHT and consequently prevent target organ damage

Hoshide, S., Parati, G., Matsui, Y., Shibazaki, S., Eguchi, K., Kario, K. (2012). Orthostatic hypertension: home blood pressure monitoring for detection and assessment of treatment with doxasosin. HYPERTENSION RESEARCH, 35, 100-106 [10.1038/hr.2011.156].

Orthostatic hypertension: home blood pressure monitoring for detection and assessment of treatment with doxasosin

Parati, G;
2012

Abstract

To determine the role of home blood pressure (BP) monitoring for a reproducible assessment of orthostatic hypertension (OHT) and the effectiveness of hypertension control by doxazosin. In this study, 605 medicated hypertensive outpatients were enrolled. Home BP in the sitting and standing positions was monitored in all patients in the morning and evening for 6 months. According to an open-label multicenter trial design, the patients were randomly allocated to either an intervention group that took doxazosin (1-4 mg) at bedtime or to a control group that did not receive any add-on medication. The patients were divided into deciles of orthostatic BP change as evaluated by home BP monitoring at baseline. Those in the top decile, in the lowest decile and in deciles two through eight were then assigned to the OHT group, the orthostatic hypotension group and the orthostatic normotension group, respectively. Orthostatic BP in the OHYPO group did not change, whereas that of the OHT group was markedly reduced by doxazosin (P<0.01). In the control group, classification into orthostatic BP categories using home BP monitoring was more reproducible (kappa coefficient: 0.42-0.50) than when using clinical BP (kappa coefficient: 0.13-0.24). In all groups, a reduction in the urinary albumin/creatinine ratio was significantly associated with a reduction in orthostatic BP doxazosin (P<0.001). The identification of OHT based on home BP monitoring was highly reproducible. The administration of doxazosin might control OHT and consequently prevent target organ damage
Articolo in rivista - Articolo scientifico
doxazosin; home blood pressure; orthostatic hypertension; urinary albumin
English
2012
35
100
106
reserved
Hoshide, S., Parati, G., Matsui, Y., Shibazaki, S., Eguchi, K., Kario, K. (2012). Orthostatic hypertension: home blood pressure monitoring for detection and assessment of treatment with doxasosin. HYPERTENSION RESEARCH, 35, 100-106 [10.1038/hr.2011.156].
File in questo prodotto:
File Dimensione Formato  
Orthostatic hypertension-Hypertension Research 2012.pdf

Solo gestori archivio

Dimensione 366.83 kB
Formato Adobe PDF
366.83 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/32171
Citazioni
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 20
Social impact