Obstructive sleep apnoea (OSA) is a common disorder, in which loss of pharyngeal dilator muscle tone during sleep causes recurrent collapse of the upper airway and temporary cessation of breathing. Repeated apneas and hypopneas lead to cycles of intermittent hypoxia/hypercapnia, increased negative intrathoracic pressure and arousals from sleep. These consequences of OSA are associated with a cascade of cardiovascular and neurohumoral consequences, including sympathetic nervous system hyperactivity, raised heart rate variability, increases in blood pressure, myocardial wall stress, oxidative stress, systemic inflammation, platelet aggregation and impaired vascular endothelial function, which contribute, in turn, to increased cardiovascular risk and, in particular, to the development of chronic systemic arterial hypertension and arrhythmias, especially atrial fibrillation (AF). Given that the prevalence of OSA is modified by age and gender, OSA-related cardiovascular diseases may also be affected by the same factors. This review focuses on the potential role of OSA in systemic arterial hypertension and AF, and discusses the most interesting studies on age and gender as predisposing factors.

Perger, E., Pengo, M., Lombardi, C. (2019). Hypertension and atrial fibrillation in obstructive sleep apnea: Is it a menopause issue?. MATURITAS, 124, 32-34 [10.1016/j.maturitas.2019.02.012].

Hypertension and atrial fibrillation in obstructive sleep apnea: Is it a menopause issue?

Perger E.
Primo
;
Pengo M. F.;Lombardi C.
Ultimo
2019

Abstract

Obstructive sleep apnoea (OSA) is a common disorder, in which loss of pharyngeal dilator muscle tone during sleep causes recurrent collapse of the upper airway and temporary cessation of breathing. Repeated apneas and hypopneas lead to cycles of intermittent hypoxia/hypercapnia, increased negative intrathoracic pressure and arousals from sleep. These consequences of OSA are associated with a cascade of cardiovascular and neurohumoral consequences, including sympathetic nervous system hyperactivity, raised heart rate variability, increases in blood pressure, myocardial wall stress, oxidative stress, systemic inflammation, platelet aggregation and impaired vascular endothelial function, which contribute, in turn, to increased cardiovascular risk and, in particular, to the development of chronic systemic arterial hypertension and arrhythmias, especially atrial fibrillation (AF). Given that the prevalence of OSA is modified by age and gender, OSA-related cardiovascular diseases may also be affected by the same factors. This review focuses on the potential role of OSA in systemic arterial hypertension and AF, and discusses the most interesting studies on age and gender as predisposing factors.
Articolo in rivista - Review Essay
Atrial fibrillation; Cardiovascular diseases; Hypertension; Menopause; Sleep apnea; Arterial Pressure; Atrial Fibrillation; Female; Humans; Hypertension; Menopause; Prevalence; Risk Factors; Sleep Apnea, Obstructive
English
2019
124
32
34
none
Perger, E., Pengo, M., Lombardi, C. (2019). Hypertension and atrial fibrillation in obstructive sleep apnea: Is it a menopause issue?. MATURITAS, 124, 32-34 [10.1016/j.maturitas.2019.02.012].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/321542
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