Multivalency is widely used in nature in specific recognition processes. This paper describes an approach to multivalency in the pentameric 5-HT3 receptor, a ligand-gated ion channel, which constitutes an example of intrinsically multivalent biological receptors. Owing to the picomolar Ki value, TETRA-L represents an outstanding multivalent ligand for the neurotransmitter receptor. © The Partner Organisations 2014.
Paolino, M., Mennuni, L., Giuliani, G., Anzini, M., Lanza, M., Caselli, G., et al. (2014). Dendrimeric tetravalent ligands for the serotonin-gated ion channel. CHEMICAL COMMUNICATIONS, 50(62), 8582-8585 [10.1039/c4cc02502d].
Dendrimeric tetravalent ligands for the serotonin-gated ion channel
Galimberti C.;
2014
Abstract
Multivalency is widely used in nature in specific recognition processes. This paper describes an approach to multivalency in the pentameric 5-HT3 receptor, a ligand-gated ion channel, which constitutes an example of intrinsically multivalent biological receptors. Owing to the picomolar Ki value, TETRA-L represents an outstanding multivalent ligand for the neurotransmitter receptor. © The Partner Organisations 2014.
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(2014) Dendrimeric tetravalent ligands for the serotonin-gated ion channel (Paolino) ChemComm 2014.pdf
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