A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous flow chemical processing. The flow cell, operated with ATR technology, is attached directly into a reaction flow stream using standard OmniFit (HPLC) connections and can be used in combination with both meso- and microscale flow chemistry equipment. The iC IR analysis software (version 4.0) enables the monitoring of reagent consumption and product formation, aiding the rapid optimisation of procedures. Short-lived reactive intermediates can also be observed in situ, giving further mechanistic insight into complex transformations.
CARTER Catherine, F., Lange, H., LEY Steven, V., BAXENDALE Ian, R., Wittkamp, B., GOODE Jon, G., et al. (2010). ReactIRTM Flow Cell - A New Analytical Tool for Continuous FlowvChemical Processing. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 14(2), 393-404 [10.1021/op900305v].
ReactIRTM Flow Cell - A New Analytical Tool for Continuous FlowvChemical Processing
LANGE Heiko;
2010
Abstract
A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous flow chemical processing. The flow cell, operated with ATR technology, is attached directly into a reaction flow stream using standard OmniFit (HPLC) connections and can be used in combination with both meso- and microscale flow chemistry equipment. The iC IR analysis software (version 4.0) enables the monitoring of reagent consumption and product formation, aiding the rapid optimisation of procedures. Short-lived reactive intermediates can also be observed in situ, giving further mechanistic insight into complex transformations.
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Carter et al. ReactIR flow cell_Org. Process Res. Dev. 2010, 14, 393-404.pdf
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