Spherical lignin particles offer a versatile platform for the development of advanced materials based on renewable resources. When their production can be coupled to simple protocols such as sonochemistry or innocuous solvent-antisolvent protocols, they become suitable tools for a wide range of biomedical and cosmetic applictions. Here, we describe generation of lignin nanoparticles in a flexible approach that additionally allows for the incorporation of actives. For such applications, another prerequisite is to use lignins with high purity, well-suited organoleptic quality, and biocompatibility. Following these criteria, a novel type of lignin nanoparticles (LNPs) was developed in a solvent-antisolvent approach. Their structural stability profile was investigated, as well as their ability to carry highly hydrophobic actives and release them in a pH-dependent manner. The application of antioxidative lignin particles as carriers for anti-inflammatory drugs is also expected to offer synergistic effects in vivo. Extensive insights into the growth mechanism are presented, that allows fine-tuning for specific applications, and the development of a general formation strategy. Characteristics of the LNPs generated by the the solvent-antisolvent approach are compared to those obtained by using sonochemistry.

Sipponen, M., Lange, H., Crestini, C. (2018). Lignin nanoparticles as vehicles for transport and active release of hydrophobic actives. In 13th World Congress of the International Society of Cosmetic Dermatology (ISCD) (pp.4).

Lignin nanoparticles as vehicles for transport and active release of hydrophobic actives

Lange, H;
2018

Abstract

Spherical lignin particles offer a versatile platform for the development of advanced materials based on renewable resources. When their production can be coupled to simple protocols such as sonochemistry or innocuous solvent-antisolvent protocols, they become suitable tools for a wide range of biomedical and cosmetic applictions. Here, we describe generation of lignin nanoparticles in a flexible approach that additionally allows for the incorporation of actives. For such applications, another prerequisite is to use lignins with high purity, well-suited organoleptic quality, and biocompatibility. Following these criteria, a novel type of lignin nanoparticles (LNPs) was developed in a solvent-antisolvent approach. Their structural stability profile was investigated, as well as their ability to carry highly hydrophobic actives and release them in a pH-dependent manner. The application of antioxidative lignin particles as carriers for anti-inflammatory drugs is also expected to offer synergistic effects in vivo. Extensive insights into the growth mechanism are presented, that allows fine-tuning for specific applications, and the development of a general formation strategy. Characteristics of the LNPs generated by the the solvent-antisolvent approach are compared to those obtained by using sonochemistry.
relazione (orale)
Lignin; nanoparticles; entrapment; delivery; release.
English
13th World Congress of the International Society of Cosmetic Dermatology (ISCD)
2018
International Society of Cosmetic Dermatology
13th World Congress of the International Society of Cosmetic Dermatology (ISCD)
2018
4
reserved
Sipponen, M., Lange, H., Crestini, C. (2018). Lignin nanoparticles as vehicles for transport and active release of hydrophobic actives. In 13th World Congress of the International Society of Cosmetic Dermatology (ISCD) (pp.4).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/320638
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