Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a tool for real-time detection of hazardous azide contaminants. This azide synthesis and purification process was then incorporated into a multistep flow sequence to generate a small collection of 5-amino-4-cyano-1,2,3-triazoles directly from aniline starting materials in a fully automated fashion.
Smith, C., Nikbin, N., Baxendale, I., Lange, H., Ley, S. (2011). Fully Automated, Multistep Flow Synthesis of 5-Amino-4-cyano-1,2,3-triazoles. ORGANIC & BIOMOLECULAR CHEMISTRY, 9(6), 1938-1947 [10.1039/c0ob00815j].
Fully Automated, Multistep Flow Synthesis of 5-Amino-4-cyano-1,2,3-triazoles
Lange, H
;
2011
Abstract
Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a tool for real-time detection of hazardous azide contaminants. This azide synthesis and purification process was then incorporated into a multistep flow sequence to generate a small collection of 5-amino-4-cyano-1,2,3-triazoles directly from aniline starting materials in a fully automated fashion.
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