Monocytes play a crucial role in immunity and tissue homeostasis. They constitute the first line of defense during the inflammatory process, playing a role in the pathogenesis and progression of diseases, making them an attractive therapeutic target. They are heterogeneous in morphology and surface marker expression, which suggest different molecular and physiological properties. Recent evidences have demonstrated their ability to enter the brain, and, as a consequence, their hypothetical role in different neurodegenerative diseases. In this review, we will discuss the current knowledge about the correlation between monocyte dysregulation in the brain and/or in the periphery and neurological diseases in humans. Here we will focus on the most common neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and multiple sclerosis.

Savinetti, I., Papagna, A., Foti, M. (2021). Human Monocytes Plasticity in Neurodegeneration. BIOMEDICINES, 9(7) [10.3390/biomedicines9070717].

Human Monocytes Plasticity in Neurodegeneration

Savinetti, I.
Primo
Membro del Collaboration Group
;
Papagna, A.
Secondo
Membro del Collaboration Group
;
Foti, M.
Ultimo
Membro del Collaboration Group
2021

Abstract

Monocytes play a crucial role in immunity and tissue homeostasis. They constitute the first line of defense during the inflammatory process, playing a role in the pathogenesis and progression of diseases, making them an attractive therapeutic target. They are heterogeneous in morphology and surface marker expression, which suggest different molecular and physiological properties. Recent evidences have demonstrated their ability to enter the brain, and, as a consequence, their hypothetical role in different neurodegenerative diseases. In this review, we will discuss the current knowledge about the correlation between monocyte dysregulation in the brain and/or in the periphery and neurological diseases in humans. Here we will focus on the most common neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and multiple sclerosis.
Articolo in rivista - Review Essay
Epigenetics; Gene expression; Human monocytes; Innate immunity; Neurodegeneration; Single cells analysis; Trained immunity;
English
23-giu-2021
2021
9
7
717
open
Savinetti, I., Papagna, A., Foti, M. (2021). Human Monocytes Plasticity in Neurodegeneration. BIOMEDICINES, 9(7) [10.3390/biomedicines9070717].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/318322
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