Magnetic Resonance Imaging (MRI) using paramagnetic systems as contrast agents is receiving increased attention as diagnostic tool in the clinic. At the same time, NMR of paramagnetic systems can also be applied in biochemical fields; for example, the use of Paramagnetic Relaxation Enhancement (PRE) allows structure refinement and the analysis of transient dynamic processes involved in macromolecular complex formation. Herein we report the synthesis and computational characterization of a new DOTA-like sialic acid conjugate, which can be used both in MRI and PRE applications when coordinated to a suitable paramagnetic metal. (C) 2012 Elsevier Ltd. All rights reserved.

Bini, D., Gregori, M., Cosentino, U., Moro, G., Canales, A., Capitoli, A., et al. (2012). Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications. CARBOHYDRATE RESEARCH, 354, 21-31 [10.1016/j.carres.2012.03.002].

Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications

BINI, DAVIDE;GREGORI, MARIA;COSENTINO, UGO RENATO;MORO, GIORGIO;CAPITOLI, ALICE;CIPOLLA, LAURA FRANCESCA
2012

Abstract

Magnetic Resonance Imaging (MRI) using paramagnetic systems as contrast agents is receiving increased attention as diagnostic tool in the clinic. At the same time, NMR of paramagnetic systems can also be applied in biochemical fields; for example, the use of Paramagnetic Relaxation Enhancement (PRE) allows structure refinement and the analysis of transient dynamic processes involved in macromolecular complex formation. Herein we report the synthesis and computational characterization of a new DOTA-like sialic acid conjugate, which can be used both in MRI and PRE applications when coordinated to a suitable paramagnetic metal. (C) 2012 Elsevier Ltd. All rights reserved.
Articolo in rivista - Articolo scientifico
Magnetic Resonance Imaging; Molecular modelling; Paramagnetic Relaxation Enhancement; Sialic acid
English
2012
354
21
31
none
Bini, D., Gregori, M., Cosentino, U., Moro, G., Canales, A., Capitoli, A., et al. (2012). Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications. CARBOHYDRATE RESEARCH, 354, 21-31 [10.1016/j.carres.2012.03.002].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/31772
Citazioni
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
Social impact