Elevated levels of interleukin (IL)-7 are present in the blood of HIV-positive patients and it is known that IL-7 receptor (IL-7R)alpha expression decreases on T cells during HIV infection. The subset(s) of T cells with low IL-7Ralpha and the consequence of low IL-7Ralpha expression for T-cell survival are poorly characterized.

Rethi, B., Fluur, C., Atlas, A., Krzyzowska, M., Mowafi, F., Grützmeier, S., et al. (2005). Loss of IL-7Rα is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients. AIDS, 19(18), 2077-2086 [10.1097/01.aids.0000189848.75699.0f].

Loss of IL-7Rα is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients

BELLOCCO, RINO;
2005

Abstract

Elevated levels of interleukin (IL)-7 are present in the blood of HIV-positive patients and it is known that IL-7 receptor (IL-7R)alpha expression decreases on T cells during HIV infection. The subset(s) of T cells with low IL-7Ralpha and the consequence of low IL-7Ralpha expression for T-cell survival are poorly characterized.
Articolo in rivista - Articolo scientifico
Apoptosis; Humans; Lymphopenia; Receptors, Interleukin-7; Cell Survival; RNA, Messenger; Cross-Sectional Studies; Down-Regulation; Cells, Cultured; HIV Infections; Adult; Antigens, CD28; Interleukin-7; Female; Male; T-Lymphocyte Subsets
English
2-dic-2005
19
18
2077
2086
none
Rethi, B., Fluur, C., Atlas, A., Krzyzowska, M., Mowafi, F., Grützmeier, S., et al. (2005). Loss of IL-7Rα is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients. AIDS, 19(18), 2077-2086 [10.1097/01.aids.0000189848.75699.0f].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/31741
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