It's the water that matters. Pairs of benzo- and perfluorobenzoarylsulfonamide ligands bind to human carbonic anhydrase with a conserved binding geometry, an enthalpy-driven binding, and indistinguishable binding affinities (see picture). These data support the pervasive theory that the lock-and-key model disregards an important component of binding: the water, which fills the binding pocket of the protein and surrounds the ligand.

LOCKETT Matthew, R., Lange, H., Bretiten, B., Heroux, A., Sherman, W., Rappoport, D., et al. (2013). The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 52(30), 7714-7717 [10.1002/ange.201301813].

The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand

LANGE Heiko
Co-primo
;
2013

Abstract

It's the water that matters. Pairs of benzo- and perfluorobenzoarylsulfonamide ligands bind to human carbonic anhydrase with a conserved binding geometry, an enthalpy-driven binding, and indistinguishable binding affinities (see picture). These data support the pervasive theory that the lock-and-key model disregards an important component of binding: the water, which fills the binding pocket of the protein and surrounds the ligand.
Articolo in rivista - Articolo scientifico
Biomolecular recognition, carbonic anhydrase, hydrophobic effect, protein-ligand binding, water.
English
2013
52
30
7714
7717
reserved
LOCKETT Matthew, R., Lange, H., Bretiten, B., Heroux, A., Sherman, W., Rappoport, D., et al. (2013). The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 52(30), 7714-7717 [10.1002/ange.201301813].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/316878
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