Privileged scaffolds as starting points toward biologically active molecules represent a neuralgic point in drug discovery. The ability of synthetic chemists concerned with their generation should be flanked by robust technologies enabling the efficient synthesis and decoration of large libraries for extensive screenings and for scale-up processes. The use of continuous flow chemistry in the pharmaceutical chemistry sector may facilitate privileged scaffold generation and implementation of more efficient multistep transformations which can contribute to developing green and sustainable processes. This review discusses the use of flow chemistry applied to the synthesis of privileged scaffolds, considering also sustainability and green chemistry aspects. Flow protocols are discussed in a unified fashion such as to facilitate effective comparison between both the various chemical approaches used on the one hand, and the chosen technical solutions across the various works on the other hand. The review also offers an authors’ perspective on potential future directions in the field.

Alfano, A., Brindisi, M., Lange, H. (2021). Flow synthesis approaches to privileged scaffolds - recent routes reviewed for green and sustainable aspects. GREEN CHEMISTRY, 23(6), 2233-2292 [10.1039/d0gc03883k].

Flow synthesis approaches to privileged scaffolds - recent routes reviewed for green and sustainable aspects

Lange H.
2021

Abstract

Privileged scaffolds as starting points toward biologically active molecules represent a neuralgic point in drug discovery. The ability of synthetic chemists concerned with their generation should be flanked by robust technologies enabling the efficient synthesis and decoration of large libraries for extensive screenings and for scale-up processes. The use of continuous flow chemistry in the pharmaceutical chemistry sector may facilitate privileged scaffold generation and implementation of more efficient multistep transformations which can contribute to developing green and sustainable processes. This review discusses the use of flow chemistry applied to the synthesis of privileged scaffolds, considering also sustainability and green chemistry aspects. Flow protocols are discussed in a unified fashion such as to facilitate effective comparison between both the various chemical approaches used on the one hand, and the chosen technical solutions across the various works on the other hand. The review also offers an authors’ perspective on potential future directions in the field.
Articolo in rivista - Articolo scientifico
privileged scaffolds, flow chemistry, heterocycles, synthesis, green chemistry, sustainable chemistry.
English
11-feb-2021
2021
23
6
2233
2292
reserved
Alfano, A., Brindisi, M., Lange, H. (2021). Flow synthesis approaches to privileged scaffolds - recent routes reviewed for green and sustainable aspects. GREEN CHEMISTRY, 23(6), 2233-2292 [10.1039/d0gc03883k].
File in questo prodotto:
File Dimensione Formato  
Alfano et al. Flow for privileged scaffolds_GreenChem. 2021,23, 2233–2292.pdf

Solo gestori archivio

Descrizione: Articolo principale
Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 17.02 MB
Formato Adobe PDF
17.02 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/316864
Citazioni
  • Scopus 40
  • ???jsp.display-item.citation.isi??? 36
Social impact