A robust two-enzyme system composed of an immobilized ketoreductase (KRED1-Pglu) and a glucose dehydrogenase (BmGDH) was developed via immobilization on aldehyde agarose for the stereoselective reduction of different ketones. The immobilized ketoreductase/glucose dehydrogenase system was continuously used in a flow reactor for weeks, even in the presence of concentrations of DMSO up to 20%.
Dall'Oglio, F., Contente, M., Conti, P., Molinari, F., Monfredi, D., Pinto, A., et al. (2017). Flow-based stereoselective reduction of ketones using an immobilized ketoreductase/glucose dehydrogenase mixed bed system. CATALYSIS COMMUNICATIONS, 93(April 2017), 29-32 [10.1016/j.catcom.2017.01.025].
Flow-based stereoselective reduction of ketones using an immobilized ketoreductase/glucose dehydrogenase mixed bed system
Serra I.
2017
Abstract
A robust two-enzyme system composed of an immobilized ketoreductase (KRED1-Pglu) and a glucose dehydrogenase (BmGDH) was developed via immobilization on aldehyde agarose for the stereoselective reduction of different ketones. The immobilized ketoreductase/glucose dehydrogenase system was continuously used in a flow reactor for weeks, even in the presence of concentrations of DMSO up to 20%.
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