Binary nano-biocomposite 3D scaffolds of cellulose nanocrystals (CNCs) - gelatin were fabricated without the use of chemical cross-linking additives. Controlled oxidative treatment allowed the introduction of carboxyl or carbonyl functionalities on the surface of CNCs that were responsible for the cross-linking of gelatin polymers. The obtained composites were characterized for their physico-chemical properties, and their biocompatibility towards different cell cultures was eval-uated through MTT and LDH assays, cellular adhesion and proliferation experiments. Gelatin composites reinforced with carbonyl-modified CNCs showed the most performing swell-ing/degradation profile and the most promising adhesion and proliferation properties towards cell lines, suggesting their potential application in the field of tissue engineering

Zoia, L., Binda, A., Cipolla, L., Rivolta, I., La Ferla, B. (2021). Binary biocompatible CNCs-Gelatine hydrogel as 3D scaffolds suitable for cell culture adhesion and growth. APPLIED NANO, 2, 118-127 [10.3390/applnano2020010].

Binary biocompatible CNCs-Gelatine hydrogel as 3D scaffolds suitable for cell culture adhesion and growth

Zoia, L
Primo
;
Binda, A;Cipolla, L;Rivolta, I;La Ferla, B
2021

Abstract

Binary nano-biocomposite 3D scaffolds of cellulose nanocrystals (CNCs) - gelatin were fabricated without the use of chemical cross-linking additives. Controlled oxidative treatment allowed the introduction of carboxyl or carbonyl functionalities on the surface of CNCs that were responsible for the cross-linking of gelatin polymers. The obtained composites were characterized for their physico-chemical properties, and their biocompatibility towards different cell cultures was eval-uated through MTT and LDH assays, cellular adhesion and proliferation experiments. Gelatin composites reinforced with carbonyl-modified CNCs showed the most performing swell-ing/degradation profile and the most promising adhesion and proliferation properties towards cell lines, suggesting their potential application in the field of tissue engineering
Articolo in rivista - Articolo scientifico
3D-scaffold, Gelatin, Cellulose Nanocrystals, Tissue Engineering
English
118
127
10
Zoia, L., Binda, A., Cipolla, L., Rivolta, I., La Ferla, B. (2021). Binary biocompatible CNCs-Gelatine hydrogel as 3D scaffolds suitable for cell culture adhesion and growth. APPLIED NANO, 2, 118-127 [10.3390/applnano2020010].
Zoia, L; Binda, A; Cipolla, L; Rivolta, I; La Ferla, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/315608
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