Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.

Gerussi, A., Natalini, A., Antonangeli, F., Mancuso, C., Agostinetto, E., Barisani, D., et al. (2021). Immune-mediated drug-induced liver injury: Immunogenetics and experimental models. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(9) [10.3390/ijms22094557].

Immune-mediated drug-induced liver injury: Immunogenetics and experimental models

Gerussi A.
;
Mancuso C.;Barisani D.;Invernizzi P.
2021

Abstract

Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.
Articolo in rivista - Review Essay
Autoimmune hepatitis; Autoimmunity; Drug-induced liver injury; Genetics; Inflammation;
English
27-apr-2021
2021
22
9
4557
none
Gerussi, A., Natalini, A., Antonangeli, F., Mancuso, C., Agostinetto, E., Barisani, D., et al. (2021). Immune-mediated drug-induced liver injury: Immunogenetics and experimental models. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(9) [10.3390/ijms22094557].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/314738
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